2-thiouridine Analysis Service

    2-Thiouridine, a modified nucleoside, is found in tRNAs and plays a crucial role in maintaining the proper reading frame during translation. It is also a part of the anticodon loop of certain tRNA molecules, contributing to the precision and efficiency of protein synthesis. 2-thiouridine has a sulfur atom replacing an oxygen molecule at the 2-position of uridine. This chemical modification enhances the stability of the tRNA structure and the accuracy of translation. 2-thiouridine is synthesized from uridine through a series of enzymatic reactions that involve the activities of thiouridylate synthase and tRNA thiolation enzymes.

     

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    Figure 1. The Structure of 2-thiouridine

     

    Understanding the behavior and dynamics of 2-thiouridine has fundamental implications in various fields, including molecular biology, genetic engineering, and human health. The regulation of 2-thiouridine is closely related to several diseases, such as neurodegenerative diseases and cancers. Therefore, 2-thiouridine analysis contributes significantly to the development of therapeutic strategies for such health conditions.

     

    MtoZ Biolabs is proud to present our specialized 2-Thiouridine Analysis Service. We utilize advanced LC-MS/MS technologies for the accurate quantification and characterization of 2-Thiouridine. Our team of experts ensures high-quality data and efficient results.

     

    Analysis Workflow

     

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    Service Advantages

    MtoZ Biolabs offers professional solutions for metabolomics research needs. With our wealth of experience and high-end facilities, we assure:

    • Highly sensitive and accurate results
    • Professional scientific support
    • Rapid turnaround time
    • Competitive prices

     

    Applications

    • Drug Research and Development
    • Biomarker Discovery
    • Disease Diagnosis

     

    Sample Submission Requirements

    1. Sample Types

    Serum, plasma, urine, tissues and other biological samples. It is necessary to prepare more than 3 biological replicates for each sample.

     

    2. Sample Volume

    • Animal tissue ≥ 100 mg
    • Plant tissue ≥ 200 mg
    • Serum/ Plasma ≥ 200 μL
    • Urine ≥ 2 mL

     

    3. Sample Preservation

    Store at -80°C to maintain stability.

     

    Note: Provide details on sample collection and handling.

     

    Deliverables

    1. Experimental Procedures

    2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

    3. Detailed Information on 2-thiouridine

    4. Raw Data

    5. Custom Analysis Report

     

    At MtoZ Biolabs, we are dedicated to providing you with robust 2-Thiouridine analysis to propel your research forward. Contact us today to learn more about how we can assist you in your research journey.

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