2'-O-methylguanosine Analysis Service

2'-O-methylguanosine is a modified nucleoside, characterized by the addition of a methyl group to the 2'-hydroxyl group of the ribose sugar in guanosine. It is produced in tRNAs by the action of tRNA guanosine-2'-O-methyltransferase. 2'-O-methylguanosine plays a crucial role in the post-transcriptional modification of cellular RNAs. It is found in many organisms, from bacteria to humans, and its alteration has been associated with various diseases, including cancers and neurological disorders. The metabolic pathways of 2'-O-methylguanosine are complex, involving multiple enzymes and regulatory molecules.

 



 

Figure 1. The Structure of 2'-O-methylguanosine

 

At MtoZ Biolabs, we are committed to providing a comprehensive analysis service for 2'-O-methylguanosine. We have a reliable analytical platform for 2'-O-methylguanosine, which combines advanced liquid chromatography-mass spectrometry (LC-MS) methods with our professional expertise in metabolomics. Our service can provide quantitative analysis of 2'-O-methylguanosine, and help you understand the metabolic pathways and regulatory mechanisms of this important molecule.

 

Analysis Workflow

 



 

Service Advantages

• State-of-the-art LC-MS/MS platforms allow us to accurately and reliably quantify 2'-O-methylguanosine in various types of samples.
• A team of experts in mass spectrometry and metabolomics provides professional data analysis and interpretation.
• One-stop service from sample preparation, LC-MS/MS analysis to data analysis, saving your time and efforts.
• Competitive price with high-quality service.

 

Applications

• Biomarker discovery
• Disease diagnosis and prognosis
• Drug response prediction
• Basic biological research

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.

 

2. Sample Volume

• Animal tissue ≥ 100 mg
• Plant tissue ≥ 200 mg
• Serum/ Plasma ≥ 200 μL
• Urine ≥ 2 mL

 

3. Storage and Shipping

Samples should be stored at -80℃ and shipped with dry ice. Avoid repeated cycles of freezing and thawing

 

Note: Please provide details on sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on 2'-O-methylguanosine

4. Raw Data

5. Custom Analysis Report

 

At MtoZ Biolabs, we are dedicated to providing top-quality service to our clients. Please contact us for more information about our 2'-O-methylguanosine analysis service, and let us be your reliable partner in your research journey.