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    17α-Hydroxyprogesterone Analysis Service

      17α-Hydroxyprogesterone (17-OHP, chemical formula C21H30O3) is a steroid hormone that belongs to the pregnane class of compounds. Its chemical structure consists of a steroid backbone composed of four carbon rings (A, B, C, D rings). It has a hydroxyl group (-OH) attached to the 17th carbon and a ketone group (-C=O) attached to the 3rd carbon. 17α-Hydroxyprogesterone itself has some biological activity, but its primary role is as a precursor to cortisol and androgens. In the adrenal glands, 17-OHP is converted into cortisol through the combined actions of 17α-hydroxylase and 21-hydroxylase. As such, 17-OHP is an important intermediate in the synthesis of glucocorticoids and androgens. Its direct biological activity in the body is limited, but abnormal levels of 17-OHP can indicate metabolic disorders. 17α-Hydroxyprogesterone is further metabolized in the body by 21-hydroxylase (CYP21A2) to form 11-deoxycortisol, which is ultimately converted into cortisol. Additionally, 17-OHP can be metabolized through other pathways to form androgens such as androstenedione. Therefore, the metabolism of 17-OHP is crucial for the production of glucocorticoids and androgens.

       

      The primary metabolites of 17α-hydroxyprogesterone, cortisol and androstenedione, have strong biological activity in the body. Cortisol is a glucocorticoid with anti-inflammatory, immune-modulating, and stress-response functions, while androstenedione is a key precursor in androgen synthesis, contributing to the maintenance and development of male secondary sexual characteristics. Abnormal metabolism of 17-OHP may lead to a range of endocrine and metabolic disorders. Analyzing the levels of 17α-hydroxyprogesterone and its metabolites in biological samples is of great clinical and research importance. Measurement of 17-OHP is commonly used to diagnose and monitor congenital adrenal hyperplasia (CAH), a condition in which 21-hydroxylase deficiency leads to an accumulation of 17-OHP. Additionally, assessing 17-OHP levels can help evaluate an individual's glucocorticoid and androgen metabolism, particularly in endocrine disorders and diseases such as polycystic ovary syndrome (PCOS) in women. The application of mass spectrometry and other high-sensitivity analytical methods allows for precise measurement of 17α-hydroxyprogesterone and its metabolites, providing crucial data for understanding metabolic imbalances, hormone-related diseases, and therapeutic approaches. Although research on 17-OHP in plants is limited, the presence of related steroid compounds in plants could provide insights into plant responses to environmental stress.

       

      1840621619543396352-TheStructureof17α-Hydroxyprogesterone.png

      Figure 1. The Structure of 17α-Hydroxyprogesterone

       

      MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider, providing advanced metabolomicsproteomics and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. MtoZ Biolabs utilizes an LC-MS-based metabolomics research platform for the analysis of 17α-hydroxyprogesterone. We ensure the accuracy of the quantification of 17α-hydroxyprogesterone and its metabolites, as well as the comprehensiveness and precision of metabolite identification. If you are interested in our 17α-hydroxyprogesterone analysis service, please feel free to contact us at any time, and we will be fully committed to providing you with high-quality analytical services and technical support.

       

      Analysis Workflow 

       

      1840621658294571008-Workflowof17α-HydroxyprogesteroneAnalysisService.PNG

       

      Service Advantages

      1. Advance Analysis Platform: MtoZ Biolabs established an advanced 17α-hydroxyprogesterone analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

       

      2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

       

      3. High-Data-Quality: Extensive data coverage with rigorous quality control. Our advanced analysis platform consolidates all 17α-hydroxyprogesterone analysis data, delivering clients a detailed and comprehensive data report.

       

      4. Quick Turnaround: We offer a fast analysis process to ensure that clients receive high-quality data within a short time.

       

      Applications

      • Studying reproductive and adrenal disorders
      • Diagnosing congenital adrenal hyperplasia (CAH)
      • Investigating infertility issues
      • Advancing the discovery of novel therapeutics

       

      Sample Submission Requirements

      1. Sample Types

      Serum, plasma, urine, and other biological samples. For each sample, it is necessary to select more than 3 materials with the same condition. 

       

      2. Sample Volume

      • Human/ Animal Tissue ≥ 100 mg
      • Serum/ Plasma ≥ 200 μL
      • Urine ≥ 2 mL

       

      3. Sample Preservation

      Samples should be stored at -80°C to maintain stability.

       

      Note: Please provide specific details regarding sample collection and handling.

       

      Deliverables

      1. Experimental Procedures

      2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

      3. Detailed Information on 17α-Hydroxyprogesterone

      4. Raw Data

      5. Custom Analysis Report

       

      Through our 17α-hydroxyprogesterone analysis service, we strive to support your research and product development by delivering accurate and reliable results.

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