1-methyladenosine Analysis Service
- Highly Efficient Sample Recovery and Processing
- Accurate and Reliable Detection and Quantification
- Capability to Handle Various Sample Types
- Customized Data Analysis Services
- Rapid Service Response and Cost-Effectiveness
- Basic Biological Research: Revealing the roles of m1A modifications in RNA stability, translation, and functions.
- Disease Research: Discovering novel m1A-based biomarkers for disease diagnosis and prognosis.
- Drug Discovery: Exploring m1A-targeted therapeutic strategies.
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
1-Methyladenosine (m1A) is a post-transcriptional modification of adenosine that occurs across various RNA species. The modification involves methylation at the nitrogen-1 position of adenine, which impacts RNA's structural conformation, stability, and its base-pairing properties. These changes play a crucial role in regulating RNA function, gene expression, and overall cellular processes. In particular, m1A has been found to influence translation efficiency and cellular response under stress conditions, contributing to the fine-tuning of protein synthesis.
The study of 1-methyladenosine is essential not only for understanding its role in normal physiological processes but also for exploring its implications in disease pathology. In recent years, m1A has garnered significant attention due to its association with human diseases, particularly cancer. 1-methyladenosine have been identified as potential tumor markers, with increased m1A levels linked to cancer progression. Research has shown that m1A can drive liver tumorigenesis by upregulating PPARδ expression, which regulates cholesterol metabolism, and by activating the Hedgehog signaling pathway.
Figure 1. The Structure of 1-methyladenosine
At MtoZ Biolabs, we provide a professional 1-methyladenosine analysis service, utilizing advanced LC-MS/MS platforms coupled with our sophisticated bioinformatics tools. Our service supports the identification and quantification of m1A modifications within RNA molecules, provides insights into its metabolic pathways, and investigates its potential links to disease. We are dedicated to providing the most reliable, comprehensive, and high-throughput m1A analysis.
Analysis Workflow
Service Advantages
Applications
Our m1A analysis service can be applied in various research fields, including but not limited to:
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice. Avoid repeated cycles of freezing and thawing
Note: Please provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 1-methyladenosine
4. Raw Data
5. Custom Analysis Report
Welcome to contact us for more information about our 1-methyladenosine Analysis Service. MtoZ Biolabs is looking forward to cooperating with you in the near future.
How to order?
