What Does Each Letter Represent in the COG Database? Is "mot" a Subcategory of "M" in COG Annotation?

In the Clusters of Orthologous Groups (COG) classification system, each letter corresponds to a specific functional category:

 

INFORMATION STORAGE AND PROCESSING

[J] Translation, ribosomal structure, and biogenesis

[A] RNA processing and modification

[K] Transcription

[L] Replication, recombination, and repair

[B] Chromatin structure and dynamics

 

CELLULAR PROCESSES AND SIGNALING

[D] Cell cycle control, cell division, chromosome partitioning

[Y] Nuclear structure

[V] Defense mechanisms

[T] Signal transduction mechanisms

[M] Cell wall/membrane/envelope biogenesis

[N] Cell motility

[Z] Cytoskeleton

[W] Extracellular structures

[U] Intracellular trafficking, secretion, and vesicular transport

[O] Posttranslational modification, protein turnover, chaperones

 

METABOLISM

[C] Energy production and conversion

[G] Carbohydrate transport and metabolism

[E] Amino acid transport and metabolism

[F] Nucleotide transport and metabolism

[H] Coenzyme transport and metabolism

[I] Lipid transport and metabolism

[P] Inorganic ion transport and metabolism

[Q] Secondary metabolite biosynthesis, transport, and catabolism

 

POORLY CHARACTERIZED

[R] General function prediction only

[S] Function unknown

 

In the COG classification, if a sequence is annotated as category M, it is primarily associated with cell wall, membrane, and envelope biogenesis. The designation "mot" appears as a subcategory or a related term within M, specifically referring to cell membrane biogenesis. However, whether "mot" is officially defined as a subset of M or merely a descriptive annotation depends on the specific database and annotation framework being used.

 

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