What Are the Advantages of SRM in GC-MS Compared With SIM
SRM and SIM are two commonly used analytical modes in GC-MS, each offering distinct benefits. Compared with SIM, SRM provides the following advantages:
1. Higher Sensitivity and Selectivity
(1) Specificity: SRM simultaneously monitors both precursor and product ions, whereas SIM monitors only precursor ions. As a result, SRM more effectively minimizes background noise and potential interferences, leading to higher analytical specificity and accuracy.
(2) Sensitivity: By targeting specific precursor-product ion transitions, SRM offers enhanced sensitivity relative to SIM, making it more suitable for the detection of low-concentration analytes.
2. Enhanced Capability for Analyzing Complex Samples
In SRM mode, the application of tandem mass spectrometry significantly reduces matrix effects, thereby improving analytical accuracy in complex sample matrices.
3. Improved Control of False Positives and False Negatives
The selective monitoring of defined precursor-product ion pairs in SRM enables stricter control over false positive and false negative results, enhancing the reliability of the analysis.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
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