Ursocholic Acid Analysis Service

Ursocholic acid (UCA) is a trihydroxy bile acid predominantly found in bear bile, recognized for its significant role in bile acid metabolism and its interactions with gut microbiota. Structurally, UCA is characterized as a 5beta-cholan-24-oic acid with hydroxy groups at the 3α, 7β, and 12α positions, differentiating it from other bile acids like chenodeoxycholic acid in humans and hyocholic acid in pigs. These distinct hydroxylation patterns impart unique bioactive properties within bile acid metabolism. In the liver, UCA undergoes conjugation with taurine or glycine before being secreted into bile and subsequently metabolized further in the intestine by bacterial enzymes. These unique features make UCA particularly valuable in studies of bile acid metabolism, liver health, and gut microbiota dynamics.

 

Figure 1. Molecular Structure of Ursocholic Acid

 

MtoZ Biolabs offers Ursocholic Acid Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in UCA detection.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity

Detects very low concentrations of UCA accurately.

 

2. High Specificity

Differentiates UCA from other compounds using mass spectrometry.

 

3. Rapid Analysis

Efficient sample preparation and fast detection processes for high-throughput analysis.

 

4. High Accuracy

Strict quality control ensures accuracy and reproducibility.

 

5. Versatility

Capable of analyzing UCA and its related metabolites.

 

Sample Submission Requirements

Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Ursocholic Acid

4. Raw Data

5. Custom Analysis Report

 

Our Ursocholic Acid Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.