Differential Scanning Calorimetry (DSC) Analysis Service

Thermal stability is defined as the ability of a substance to resist irreversible chemical or physical changes at elevated temperatures, typically by preventing decomposition or polymerization. This property is particularly important in some proteins. In proteins that are sensitive to high temperatures, increased heat can disrupt the intramolecular bonds within their tertiary and quaternary structures, leading to protein unfolding and inactivation. Therefore, assessing the thermal stability of protein-based biological products is a crucial aspect of their quality control.

 

Differential Scanning Calorimetry (DSC) is a widely used technique for directly assessing the stability of proteins and other biomolecules under native conditions. The method offers efficient and precise analysis of biological products’ thermal stability. MtoZ Biolabs is equipped with Malvern Panalytical's MicroCal VP-Capillary DSC system. This automated, integrated high-throughput platform can be applied to:


1. Identifying and Selecting the Most Stable Proteins or Potential Drug Candidates During the Development of Biotherapeutic Drugs

2. Studying Ligand Interactions

3. Quickly Optimizing Purification and Production Conditions

4. Swiftly Establishing Optimal Conditions for Liquid Formulations

5. Providing Rapid Stability Indications for Target Proteins During Screening

 



Njila, S. 2018.

 

Services at MtoZ Biolabs

 



 

Deliverables

1. Experimental Procedures

2. Relevant Instrument Parameters

3. Raw Data

4. Thermal Stability Analysis Results