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    Scopolamine Analysis Service

      Scopolamine, a tropane alkaloid derived from nightshade plants and honeysuckle, exhibits potent anticholinergic properties, functioning as an antagonist at muscarinic acetylcholine receptors. Metabolized in the body through hydrolysis by carboxylesterase into scopolamine and tropic acid, it undergoes further transformation by scopolamine dehydrogenase into tropine. The cytochrome P450 enzymes, especially the CYP3A subfamily, further oxidize it, producing metabolites like norhyoscine and dihydrohyoscine. These undergo subsequent glucuronidation or sulfation for excretion.

       

      The analysis of scopolamine and its metabolites is critical for comprehending its metabolism, assessing therapeutic efficacy, and ensuring safety. This process not only elucidates the pharmacological actions of scopolamine but also aids in refining treatment regimens and tailoring dosages to individual needs, enhancing both safety and effectiveness. Additionally, meticulous monitoring and metabolic profiling are essential for new drug development and the reevaluation of existing drugs.

       

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      Figure 1. Molecular Structure of Scopolamine

       

      At MtoZ Biolabs, advanced liquid chromatography-mass spectrometry (LC-MS) is utilized to quantitatively and qualitatively analyze scopolamine and its metabolites. This provides deep insights into its metabolic processes and potential interactions, supporting both research and clinical applications.

       

      Analysis Workflow

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      Services at MtoZ Biolabs

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      Service Advantages

      • High Sensitivity and Accuracy: LC-MS technology can precisely identify and quantify trace components in complex samples.
      • Broad Applicability: Suitable for various biological samples, including plant tissues, blood, and urine.
      • Rapid Analysis: The process from sample handling to report generation is efficient, shortening the analysis cycle.
      • Customized Services: Personalized analysis solutions provided based on specific customer needs.

       

      Applications

      Clinical Drug Monitoring: Ensuring optimal dosing in neurodegenerative diseases like Parkinson’s disease to maximize benefits and minimize risks.

       

      Pharmacokinetic Studies: Optimizing drug absorption and metabolism in cardiovascular treatments.

       

      Drug Interaction Assessment: Safeguarding the efficacy and safety of scopolamine when used concurrently with chemotherapy agents in oncology.

       

      Toxicological Assessment: Conducting preclinical evaluations for new anticholinergic compounds to confirm their safety before clinical trials.

       

      Personalized Medicine: Developing tailored treatment strategies for COPD patients to reduce side effects and improve outcomes, demonstrating our commitment to patient-specific healthcare solutions.

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