Resources
Proteomics Databases

Metabolomics Databases

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• Isobaric Labeling Mass Spectrometry
Isobaric labeling mass spectrometry is a technique that introduces isotopic labels into specific biomolecules via chemical methods, facilitating quantitative and qualitative analysis using mass spectrometry. This approach finds broad applications in proteomics, particularly in the study of differential proteomics and dynamic protein changes. As biomedical research advances, the need for precise quantification and identification of proteins in complex biological systems is growing. By introducing known......
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• Label-Free Quantification Using MaxQuant
Label-Free Quantification using MaxQuant is a mass spectrometry-based proteomics analysis method primarily utilized for the relative quantification of protein abundance. As the field of proteomics rapidly evolves, there is an increasing demand for precise and efficient methods to analyze complex protein mixtures. Traditional labeling techniques such as iTRAQ and SILAC, while providing accurate quantitative data, require complex chemical labeling of samples, which is both cumbersome and costly. In cont......
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• Identification of Post-Translational Modifications
The identification of post-translational modifications (PTMs) represents a pivotal area in contemporary biological and biochemical research. PTMs refer to a series of chemical changes that proteins undergo following translation, including phosphorylation, acetylation, methylation, ubiquitination, and glycosylation. These alterations can profoundly influence protein function, stability, localization, and interactions with other molecules, thus playing a critical role in processes like cell signaling, m......
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IPA protein analysis is a specialized software tool designed for the analysis and interpretation of complex biological data. It is extensively utilized in proteomics, genomics, and transcriptomics to assist scientists in understanding the functions and mechanisms of biological systems in greater depth. By leveraging the comprehensive data resources of the Ingenuity Knowledge Base, the software provides insights into gene-protein interactions, metabolic pathways, and signaling pathways. The primary fun......
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In proteomics, GO (Gene Ontology) analysis is a method used to comprehensively describe gene attributes and the functions of gene products. In a GO analysis result graph, the x-axis typically represents GO terms, while the y-axis usually indicates the number of genes or the enrichment ratio. The interpretation of these axes is essential for understanding gene function and its role within an organism, and should be guided by the specific annotations provided in the graph. GO analysis is categorized into.....
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Antibody-Drug Conjugates (ADCs) represent an innovative class of targeted therapeutic agents, merging the specificity of monoclonal antibodies with the toxicity of small-molecule drugs. The effective design and optimization of ADC structures are paramount for maximizing therapeutic benefits while ensuring safety. This article offers a comprehensive examination of the structural components of ADCs and their critical role in biological sciences.
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• What Aspects Does Conventional Proteomics Measure
Proteomics is a discipline that studies the quality, structure and function of proteins. Conventional proteomics usually studies the following aspects: 1. Protein Quantification Protein quantification is a crucial aspect of proteomics research. Through quantitative protein analysis, we can assess protein abundance and gain insights into their physiological roles. 2. Protein-Protein Interaction Studying protein-protein interactions provides insights into protein functions within cells and their network......
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• Cell Sample Processing in Proteomics
1. Cell Separation The initial step involves the separation of cells, typically achieved through mechanical or enzymatic methods. Mechanical separation primarily involves physical methods to dissociate cells from tissue, whereas enzymatic separation utilizes enzymes to degrade intercellular connections. 2. Cell Disruption Following separation, cells require disruption to facilitate the extraction of intracellular proteins. Methods for cell disruption include sonication, freeze-thaw cycles, and chemical.....
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• Can Blood Samples Be Used for Proteomics Analysis
Proteomics is a scientific field that studies the composition, function, and structure of all proteins. Analyzing proteomics in blood samples provides a scientific approach to identifying and quantifying potential biomarkers, which are critical for disease diagnosis, prognosis, and monitoring. Collection and Processing of Samples Blood samples are typically collected via venipuncture, then either preserved through freezing or processed by centrifugation, among other methods.
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• PCF Spatial Single-Cell Proteomics
Single-cell proteomics is a scientific technique employed for the detection and quantification of proteins within individual cells. Recently, single-cell analysis has emerged as a vital tool in the realms of biology and drug development, particularly within the areas of cellular heterogeneity, developmental biology, and disease biology.
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