Resources
Proteomics Databases
Metabolomics Databases
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• Proteomics Mass Spectrometry Analysis: Principles and Key Applications
Proteomics mass spectrometry analysis is a fundamental technique in modern life sciences for studying protein composition, structure, and function. By utilizing highly sensitive mass spectrometry platforms for protein detection and quantification, this approach enables researchers to investigate dynamic changes in protein expression, post-translational modifications, and protein interactions in biological processes. Recent advancements in mass spectrometry technology have enhanced the precision and th......
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• Proteomics Analysis: Methods, Technologies, and Applications
Proteomics analysis is a scientific approach to reveal life processes by systematically studying the composition, function, and roles of proteins within cells. Unlike genomics, proteomics focuses not only on gene expression products but also on how these products contribute to biological systems through post-translational modifications, interactions, and their dynamic changes. With continuous advancements in high-throughput technologies and sophisticated analytical techniques, proteomics has become a ......
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• Protein Identification and Quantification: Techniques and Strategies
Proteins are essential to biological systems, with their structure, abundance, and dynamic changes being critical to the regulation of normal biological processes and the onset of disease. Consequently, protein identification and quantification are fundamental to fields such as basic research, disease diagnostics, and drug development. With the rapid advancement of mass spectrometry technologies and high-throughput proteomics methods in recent years, researchers can now analyze protein types and abund......
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Peptide LC-MS/MS analysis is a highly efficient method that integrates liquid chromatography (LC) and mass spectrometry (MS) techniques, predominantly utilized in proteomics research. This technique involves digesting proteins from complex biological samples into smaller peptides, which are then separated using liquid chromatography. The separated peptides undergo mass spectrometric analysis to determine their mass, allowing for both qualitative and quantitative protein assessments. A primary advantag......
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Native proteomics involves the systematic analysis and study of proteins without altering their three-dimensional structure. This approach is applicable not only to individual protein studies but also to the analysis of protein networks and inter-protein interactions. Proteins typically perform cellular functions by forming complexes with other proteins or molecules, and many biological processes, including signal transduction, gene expression regulation, and cell cycle control, depend on precise prot......
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Orbitrap proteomics is a method that systematically analyzes the proteome using Orbitrap high-resolution mass spectrometry. This advanced Fourier transform mass analyzer is notable in proteomics research for its exceptional resolution, accuracy, and sensitivity. Unlike traditional quadrupole or time-of-flight (TOF) mass spectrometers, Orbitrap technology can accurately measure the mass of proteins and peptides over a broad dynamic range with high quantitative precision, thus enhancing the reliability ......
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Label-free LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) is an efficient analytical approach that integrates liquid chromatography (LC) with mass spectrometry (MS) to enable high-precision qualitative and quantitative analysis of components within complex biological samples. The primary advantage of label-free LC-MS/MS is its ability to analyze samples without the need for chemical labeling or pretreatment, allowing direct separation and analysis. This methodology enables researchers to id......
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Metaproteomic analysis technology involves the comprehensive and systematic examination and quantification of all proteins within an organism, focusing on their composition, structure, function, and interactions using advanced mass spectrometry, liquid chromatography, and other high-throughput analytical methods. Unlike genomics and transcriptomics, this approach provides direct insights into the expression and biological roles of proteins, offering a deeper understanding of cellular physiological and......
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Fungal proteomics is a field dedicated to the comprehensive analysis of all proteins within fungal cells, utilizing high-throughput technologies. Unlike genomics, which focuses on the genes of organisms, proteomics emphasizes the expression, function, interactions, and post-translational modifications of proteins. Fungi, as microorganisms, play significant roles in ecology, agriculture, and medicine. By studying fungal proteomes, scientists can gain valuable insights into the functions of various prot......
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• Primary Structure Analysis: Key to Protein Function and Drug Design
Primary structure analysis is a pivotal technique in proteomics, focusing on detailed examination of protein molecules' amino acid sequences. Proteins execute nearly all cellular activities, such as catalyzing reactions, providing structural integrity, regulating gene expression, and transporting molecules. The function of a protein is intrinsically linked to its amino acid sequence, with even minor alterations potentially leading to significant functional changes. By elucidating the primary structure......
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