Resources

Proteomics Databases



Metabolomics Databases

• • Isoform Sequencing

  Isoform sequencing is a method used to characterize the sequences of isoforms, which are distinct transcripts or protein forms originating from the same gene. These isoforms are generated through mechanisms such as alternative splicing, alternative promoter selection, and RNA editing. This approach enables a deeper understanding of the complexity and diversity of gene expression, which is crucial for elucidating cellular functions and disease mechanisms.   Isoform sequencing examines genes or genomic ......

• • Cryogenic Electron Microscope

  Cryogenic Electron Microscope is an advanced imaging technique that leverages electron beams to visualize biological samples at ultra-low temperatures. By preserving samples in their near-native state through rapid vitrification, Cryogenic Electron Microscope offers unprecedented resolution for studying the intricate structures of biomolecules. The workflow of Cryogenic Electron Microscope involves four key steps: sample preparation, vitrification, data acquisition, and image reconstruction. Samples a......

• • Cryo Microscopy

  Cryo microscopy, also known as cryo-electron microscopy (cryo-EM), is a transformative technology for investigating the structures of biological macromolecules. By rapidly freezing samples to preserve their native states, cryo-EM captures high-resolution images without compromising structural integrity. This capability has established cryo-EM as an indispensable tool in structural biology, enabling researchers to study complex biological systems such as proteins, viruses, and cellular membranes un......

• • Single-Nuclear RNA Sequencing

  Single-nuclear RNA sequencing(snRNA-Seq) is an advanced high-throughput technology designed to analyze RNA expression at the level of individual cell nuclei. This approach has become increasingly valuable in biomedical research due to its ability to reveal cellular heterogeneity, track cell differentiation trajectories, and decipher tissue complexity. Unlike traditional methods that require whole-cell dissociation, single-nuclear RNA sequencing directly isolates RNA from intact nuclei, preserving the ......

• • Single-Cell Long-Read Sequencing

  Single-Cell Long-Read Sequencing is an advanced technology that enables the comprehensive characterization of genomic and transcriptomic information at the single-cell level. By integrating the strengths of single-cell resolution and long-read sequencing, this approach addresses limitations associated with traditional short-read sequencing methods, such as difficulties in resolving complex genomic rearrangements, identifying full-length isoforms, and analyzing gene families. Long-read sequencing gener......

• • Molecule Discovery

  Molecule discovery refers to the identification and characterization of biomolecules and their biological functions. At its core, this technology seeks to pinpoint proteins, nucleic acids, metabolites, and other critical molecules involved in specific biological processes. Beyond advancing fundamental science, molecule discovery has far-reaching applications in clinical medicine, drug development, and agricultural innovation. For instance, researchers use this approach to identify disease biomarkers, ......

• • Spatial Seq

  Spatial Seq is an innovative technique designed to acquire genomic information while preserving the spatial context of tissue sections. Unlike traditional sequencing methods, which require the dissociation of tissues or cells and result in the loss of spatial information, Spatial Seq enables high-resolution mapping of gene expression within intact tissues. This integration of spatial and genomic data allows researchers to investigate cellular behaviors and interactions within their native microenviron......

• • Single-Particle Cryo-Electron Microscopy

  Single-Particle Cryo-Electron Microscopy is a cutting-edge high-resolution technique for visualizing the structures of biological macromolecules. Unlike traditional electron microscopy, which relies on staining or fixation and often introduces artifacts or sample deformation, this method employs rapid freezing at liquid nitrogen temperatures (approximately -196°C) to preserve samples in their native states. Its key advantage lies in achieving high-resolution structures without requiring sample crystal......

• • Spatial RNA-Seq

  Spatial RNA-Seq is a cutting-edge technology that enables the precise analysis of gene expression within the spatial framework of tissue sections. By integrating RNA sequencing with spatial information, it generates localized gene expression profiles, shedding light on the roles and interactions of cells within their native microenvironments. Unlike traditional RNA sequencing, which provides genome-wide data but lacks spatial resolution, spatial RNA-Seq not only identifies the transcriptional characte......

• • HTS Screening Assays

  HTS screening assays represent a powerful methodology for rapidly and efficiently evaluating the biological activities or properties of a vast number of compounds or biological samples. By integrating automation, miniaturization, and parallelization into experimental workflows, HTS screening assays enable the analysis of tens of thousands of samples in a short time frame. This approach has become indispensable in drug discovery, functional genomics, proteomics, and other domains of life sciences.   In......