Resources
Proteomics Databases
Metabolomics Databases
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Total protein analysis determines the overall protein content in a sample. Proteins are fundamental to life, participating in nearly all physiological processes, including metabolism, signal transduction, immune response, and cellular structure maintenance. By conducting total protein analysis, researchers can gain insights into the overall protein expression levels within cells, tissues, or organisms, which is crucial for biological research, disease diagnosis, and drug development. Clinically, it is......
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Peptide-based drug design represents an innovative approach in drug development, utilizing the distinctive biological activity and specificity of peptide molecules to create therapeutics with enhanced efficacy and minimized side effects. Composed of amino acids, peptide molecules feature unique three-dimensional configurations that facilitate precise interactions with target molecules such as proteins, receptors, and enzymes, thereby influencing their biological activities. In peptide-based drug desig......
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Primary sequence analysis is a fundamental and crucial step in proteomics research, involving the detailed examination and interpretation of protein amino acid sequences. This process serves as the starting point for elucidating protein function and understanding complex molecular mechanisms within organisms. The primary objective of this analysis is to accurately map the positions and order of amino acids in proteins. Advances in technology have enhanced the efficiency and precision of this process. ......
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The amino acid analysis test is essential for elucidating the structure and function of biomolecules by determining the composition and concentration of amino acids in a given sample. Precise amino acid analysis tests are widely applied in fundamental research, medical diagnostics, food safety assessment, and biotechnology development. In fundamental research, the amino acid analysis test aids in a deeper understanding of protein structure and function. By analyzing the amino acid composition derived ......
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Plasma amino acid analysis is an experimental technique for the quantitative measurement of amino acids in blood. As fundamental components of proteins and essential participants in various metabolic pathways, amino acids hold significant importance in biomedical research and clinical diagnosis. This analysis plays a crucial role in both basic and clinical research, enabling researchers to assess an individual's nutritional status, detect hereditary metabolic disorders, monitor disease progression, an......
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• Peptide Array Epitope Mapping
Peptide array epitope mapping is a high-throughput and sensitive technique for characterizing protein epitopes, playing a crucial role in antibody research, vaccine development, immunodiagnostics, and autoimmune disease studies. This method constructs peptide arrays using short peptide fragments (typically 8-20 amino acids) that mimic the epitope conformation of target proteins. By detecting the specific interactions between antibodies (or other binding molecules) and peptide sequences, peptide array ......
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Proximity labeling assay is a widely employed experimental technique in proteomics research that aims to efficiently identify and investigate protein interactions, intracellular localization, and functions. This method enables researchers to precisely label proteins and their interacting neighbors, revealing their roles and biological processes within cells. The core principle involves using specialized labeling molecules (such as enzymes or chemical reagents) to tag proteins and adjacent molecules. S......
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Proteomic mapping systematically characterizes the protein composition, structure, and function of a specific organism, tissue, or cell under defined conditions. As an integral part of proteomics research, it provides critical insights into protein expression levels, post-translational modifications, interaction networks, and their functional roles in biological systems. With advances in high-throughput technologies, proteomic mapping has become a key tool for studying biological processes and is wide......
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TMT phosphoproteomics is a high-throughput method based on TMT quantitative labeling technology, aimed at studying the dynamic changes in protein phosphorylation and their regulatory roles in cellular signaling, disease progression, and drug effects. As one of the post-translational modifications, protein phosphorylation is crucial in various biological processes, including cell cycle regulation, metabolic control, and immune response. By integrating enrichment strategies for phosphorylation and high-......
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Activity-based proteomics is an emerging field focused on uncovering protein functions and dynamic changes by assessing their biological activities within cells. Unlike traditional proteomics, which primarily examines protein expression profiles, this field emphasizes understanding the functional states, interactions, and roles of proteins in biological processes. Central to this discipline is identifying and quantifying active proteins, which gain biological activity through specific chemical modific......
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