Resources

Proteomics Databases



Metabolomics Databases

• • Single Cell BCR Sequencing

  Single cell BCR sequencing is a high-throughput technology that enables the analysis of B cell receptor (BCR) sequences and expression profiles at single-cell resolution. BCRs are membrane-bound immunoglobulins expressed on the surface of B cells that specifically recognize foreign antigens, initiating the humoral immune response. Upon antigen exposure, B cells are activated through BCR recognition and subsequently undergo clonal expansion, somatic hypermutation, and class switching to produce.........

• • Small Molecule Discovery

  Small molecule discovery is a critical methodology in biomedical research, aiming to identify, optimize, and validate biologically active compounds from the vast and complex chemical space. These compounds are typically low-molecular-weight organic molecules capable of modulating protein activity, signaling pathways, or cellular functions, thereby contributing to advancements in drug development, chemical biology, and precision medicine. The primary objective of small molecule discovery is to identify......

• • Single Cell and Spatial Transcriptomics

  Single cell and spatial transcriptomics represent groundbreaking technologies that enable the resolution of gene expression at the single-cell level while simultaneously preserving the spatial localization of cells within tissue contexts. Conventional transcriptomic analyses, which rely on bulk cell populations, often mask cellular heterogeneity and thus limit the resolution at which complex biological systems can be understood. The emergence of single cell and spatial transcriptomics offers a ........

• • PROTAC Degradation

  PROTAC degradation represents an innovative approach to precise protein regulation, leveraging the endogenous ubiquitin–proteasome system to selectively degrade target proteins and thereby inhibit their function. Unlike traditional small-molecule inhibitors that merely suppress protein activity, PROTAC degradation removes the target protein entirely from the intracellular environment. A PROTAC (Proteolysis Targeting Chimera) is a bifunctional molecule composed of two ligands—one specific for the target.....

• • PROTACs and Molecular Glues

  PROTACs and molecular glues represent a class of small-molecule therapeutics with a revolutionary mode of action. They function by recruiting intracellular target proteins to E3 ubiquitin ligases, thereby promoting the ubiquitination of the targets and their subsequent degradation via the proteasome. This approach surpasses the conventional paradigm of merely inhibiting protein function, enabling direct elimination of disease-associated proteins and offering a novel strategy for addressing previously.......

• • Spatial Single-Cell RNA-Seq

  Spatial single-cell RNA-seq integrates single-cell RNA sequencing with spatial transcriptomics to elucidate the patterns of gene expression within tissues while preserving their precise spatial context. This approach retains spatial information at the cellular level within tissue sections, allowing the simultaneous measurement of individual transcriptomes and their spatial positioning. By bridging transcriptomic data with spatial localization, this technology offers profound insights into cellular.......

• • PROTAC Molecule

  The PROTAC molecule represents an innovative drug discovery strategy designed to selectively degrade intracellular target proteins. Unlike conventional inhibitors that block protein function, PROTAC molecules harness the cell’s endogenous protein degradation machinery to eliminate unwanted or pathogenic proteins. A PROTAC molecule consists of two essential components: a small-molecule ligand that selectively binds to the target protein and another ligand that recruits an E3 ubiquitin ligase. These two......

• • Protein Folding Assay

  The protein folding assay is a technique employed to investigate the three-dimensional structure of proteins and the mechanisms underlying their folding. The biological function of proteins is largely dependent on their proper folding, while misfolded proteins can result in cellular dysfunction and are implicated in several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Creutzfeldt-Jakob disease. Therefore, protein folding assays hold significant importance in ........

• • DDA Mass Spectrometry

  DDA mass spectrometry is a widely employed strategy for data acquisition in proteomics. Its core principle involves performing full-scan MS1 to obtain peptide ion information, followed by the automatic selection of the most intense precursor ions based on signal intensity for subsequent MS2 analysis. This approach enables the identification and quantification of proteins within complex biological samples. DDA mass spectrometry allows high-throughput protein identification, the generation of protein ........

• • Epitope Screening

  Epitope screening is a critical technique for identifying epitopes—specific regions of an antigen molecule that are recognized by the immune system. These epitopes interact with antibodies or T-cell receptors, potentially triggering an immune response. The primary goal of epitope screening is to identify antigenic protein fragments capable of effectively activating the immune system, which is essential for optimizing vaccine design, selecting high-affinity antibodies, and investigating abnormal immune......