Resources

Proteomics Databases



Metabolomics Databases

• • HDX-MS Data Interpretation

  Ion beam is a well-known type of electromagnetic wave, and the famous mass spectrometry technology is conducted with its aid. What we are going to introduce to you this time is a cutting-edge mass spectrometry technology — HDX MS. "You ask what this has to do with biopharmaceuticals?" There is much to tell!

• • Mass Spectrometry and Bioinformatics

  Proteins are important functional molecules in biological organisms, playing a key role in understanding biological processes and disease mechanisms. Mass spectrometry and bioinformatics, as two powerful analysis methods, can provide a wealth of protein information. However, the singular application of mass spectrometry or bioinformatics in protein analysis has some limitations.

• • Application of Mass Spectrometry in Drug Discovery

  Drug discovery is a complex and tedious process involving a large number of experiments and data analysis. In this process, proteins play a crucial role as drug targets. However, the accurate identification and characterization of proteins in drug development remains a challenging task. In this regard, the application of mass spectrometry technology provides effective assistance for drug discovery.

• • Proteomic Profiling of Exosomes from Plasma Samples

  Exosomes are small vesicles secreted by cells, typically ranging from 30 to 150 nm in diameter, with a membrane-bound structure. In recent years, exosomes have emerged as crucial mediators of intercellular communication, carrying molecules such as proteins, lipids, and nucleic acids that modulate physiological functions of recipient cells, either locally or distantly.

• • Quantitative Analysis of Exosomal Proteins by LC-MS/MS

  Exosomes are small vesicles with a diameter of 30 to 150 nanometers that can be secreted by various cell types. They play a key role in physiological and pathological processes, such as intercellular communication, immune regulation, and tumor metastasis. Due to their widespread distribution in the body and their cargo of proteins, lipids, and nucleic acids, exosomes reflect the state of their parent cells, making them potential biomarkers and drug delivery systems.

• • Subcellular Fractionation for Proteomics Analysis

  Subcellular fractionation is a crucial technique in biological research, especially in proteomics, where it allows the separation of distinct subcellular components from whole cells. With the advancement of proteomics, subcellular fractionation has become instrumental in analyzing the protein composition, localization, and functions of various organelles.

• • Subcellular Proteomics Analysis Based on UHPLC-MS

  Subcellular proteomics is a branch of science that investigates the composition, modifications, and dynamic changes of proteins in specific subcellular structures. This technology is critical for elucidating the roles of organelles in cellular function, as well as the distribution, function, and interactions of proteins within subcellular compartments. Subcellular proteomics enables deeper insights into complex biological processes, including signal transduction, metabolic regulation, and protein transport.

• • Proteomic Profiling of FFPE Samples Using NanoLC-MS/MS

  Formalin-fixed paraffin-embedded (FFPE) samples are indispensable biological materials in pathology and translational medicine due to their long-term preservation and wide usage. These samples are commonly used in clinical and research settings to preserve tissue samples for subsequent analysis. However, proteins in FFPE samples become difficult to extract due to crosslinking and chemical modifications, posing challenges for traditional proteomics analysis.

• • FFPE Sample Proteomics for Biomarker Discovery

  Formalin-Fixed, Paraffin-Embedded (FFPE) samples have been widely utilized in biomedical research due to their exceptional long-term stability. These samples are frequently used for histopathological diagnoses and represent an invaluable source of tissue specimens for retrospective research. Despite their utility, FFPE samples pose significant challenges in proteomic studies because of extensive protein cross-linking and denaturation.

• • Label-Free Quantitative Analysis of Plant Proteins

  Proteins are among the most crucial molecules in living organisms, participating in nearly all biological processes. Plant proteins play essential roles in growth, development, environmental adaptation, and disease resistance. To fully understand the dynamic changes and functions of plant proteins, proteomics has become an indispensable tool in biological research.