Resources

Proteomics Databases



Metabolomics Databases

• • Histone Modification Detection

  Comprehensive analysis of protein modifications represents a crucial method for investigating disease mechanisms and facilitating the development of novel therapeutics. This approach primarily employs mass spectrometry to perform extensive and precise assessments of protein modifications.

• • Detection of Post-Translational Modifications in Protein Drugs

  Post-Translational Modifications (PTMs) are chemical modifications that occur on proteins after their synthesis by mRNA translation, mediated by enzymatic activity on the protein's backbone or side chains. Types of PTMs: PTMs encompass various chemical modifications such as phosphorylation, acetylation, glycosylation, ubiquitination, and arginine methylation. These modifications alter the protein's chemical properties and charge distribution, consequently impacting protein structure and function. They can..

• • Western Blot Detection of Protein Phosphorylation Levels

  Western blotting is an immunoblotting technique extensively utilized for the detection of specific proteins within a sample. This method involves initially separating proteins via polyacrylamide gel electrophoresis (PAGE), followed by their transfer onto a membrane, and subsequent detection using specific antibodies. For assessing protein phosphorylation levels, specific antibodies targeting phosphorylated epitopes are employed. The following outlines the fundamental steps for using Western blotting to.....

• • Protein Phosphorylation Modification 4D-DIA Label-Free Quantification Technique

  Protein phosphorylation is a pivotal form of post-translational modification, essential for cellular signaling, cell cycle regulation, growth, differentiation, and apoptosis. Investigating protein phosphorylation is thus of immense scientific and clinical importance. Recently, the advent of 4D-DIA label-free quantification technology has introduced a novel approach to proteomics analysis. This method integrates ion mobility chromatography (IMC), tandem mass spectrometry (MS/MS), and data-independent........

• • Protein Chemical Sequencing Method

  Protein chemical sequencing is a pivotal biochemical technique used for elucidating the amino acid sequences of proteins. This method is essential for comprehending the architecture and functionality of proteins and is immensely valuable in drug discovery and disease diagnostics. Below, we present a detailed overview of the fundamental steps and applications of protein chemical sequencing.

• • The Importance of Glycomic Analysis

  Glycomics is a technique for investigating sugar metabolism in organisms by measuring and analyzing changes in glycan composition and concentration. This approach has extensive applications in biomedical research, food science, and biotechnology. Providing Fundamental Insights for Biochemical Research: Glycomics serves as a crucial tool in biochemical studies. Sugars are not only a major source of energy but also essential mediators in numerous biological processes. A comprehensive understanding of glycan..

• • Translate the Amino Acid Sequence of the Peptide by Mass Spectrometry Analysis

  Liquid Chromatography-Mass Spectrometry (LC-MS) is a widely used analytical technique for determining the amino acid sequences of peptides. By integrating liquid chromatography (LC) with mass spectrometry (MS), LC-MS enables comprehensive structural characterization of peptides with high sensitivity, accuracy, and resolution. Fundamental Principles of Liquid Chromatography-Mass Spectrometry: The principle of LC-MS involves two key stages: chromatographic separation followed by mass spectrometric detection.

• • Amino Acid Sequence Feature Analysis

  Amino acid sequences play a fundamental role in biological research, as they serve as the primary structural units of proteins. In bioinformatics—a field that integrates computational approaches with biological data—the analysis of amino acid sequence characteristics is a crucial task. Amino Acid Sequences: Amino acid sequences are synthesized during the translation of nucleic acids into proteins within animal cells. Each amino acid sequence encodes specific biological functions and holds significant.......

• • Analysis of Protein Chemical Modification

  Protein chemical modifications are essential physiological processes that significantly influence protein stability, localization, activity, and interactions with other molecules in living organisms. Analyzing and understanding these modifications can provide valuable insights into the complex biological activities occurring within organisms. Types of Protein Chemical Modifications: Protein chemical modifications include several types, such as phosphorylation, acetylation, methylation, ubiquitination, and..

• • The Latest Histone Modification Research

  Histone modification is a complex biochemical process that influences chromatin structure and regulates gene expression. This involves the dynamic wrapping and unwrapping of DNA and the subsequent activation or repression of genes, all of which rely on intricate biochemical reactions within the cell. Researchers have identified several types of histone modifications, including acetylation, methylation, phosphorylation, ubiquitination, and arginine methylation, each playing critical roles in various.........