ω-6 Fatty Acid Analysis Service

Polyunsaturated fatty acids (PUFAs) are primarily classified into ω-3 and ω-6 fatty acids. The difference between these two fatty acids lies in the position of the first double bond from the methyl end of the fatty acid chain. ω-6 fatty acids have a carbon-carbon double bond at the n-6 position.

 

There is competition between ω-6 and ω-3 fatty acids for desaturation enzymes. Fatty acid desaturase 1 (FADS1) and fatty acid desaturase 2 (FADS2) show a preference for α-linolenic acid (ALA) over linoleic acid (LA). However, high intake of LA, typical in Western diets, interferes with the desaturation and elongation of ALA. Similarly, trans fatty acids disrupt the desaturation and elongation of both LA and ALA.

 

ω-6 and ω-3 fatty acids are metabolically and functionally distinct and cannot be interconverted. They often have opposing physiological roles and are crucial in dietary balance. An elevated ω-6/ω-3 ratio is pro-inflammatory, contributing to atherosclerosis, obesity, and diabetes through gene expression changes, prostaglandin and leukotriene metabolism, and interleukin-1 production. High ω-6 intake promotes insulin resistance, while ω-3 intake supports homeostasis and weight loss.

 

MtoZ Biolabs offers reliable, rapid, and cost-effective ω-6 fatty acids analysis services based on high-stability, reproducible, and high-sensitivity separation, characterization, identification, and quantification systems. Free project evaluation!

 

ω-6 Fatty Acids Analysis by MtoZ Biolabs

1. Linoleic acid (LA) 18 : 2 (n-6)

2. Gamma-linolenic acid (GLA) 18 : 3 (n-6)

3. Dihomo-gamma-linolenic acid (DGLA) 20 : 3 (n-6)

4. Arachidonic acid (AA, ARA) 20 : 4 (n-6)