Molecular Cell Proteomics Service
Molecular cell proteomics is a discipline focused on studying the expression, structure, function, and interactions of proteins within cells. As a significant branch of proteomics, it delves deeply into the dynamic changes of proteins at the cellular level and their regulatory mechanisms in biological processes.
Molecular cell proteomics takes the cell as the fundamental research unit. Utilizing high-sensitivity and high-resolution technologies, it systematically analyzes the types, quantities, structures, localizations, and interactions of intracellular proteins. These proteins perform diverse functions within cells, such as enzymatic catalysis, signal transduction, cell structural maintenance, and gene expression regulation. Therefore, a comprehensive understanding of proteins is essential for elucidating cellular functions, disease mechanisms, and drug development.
Protein expression and localization within cells are regulated by multiple factors, including gene expression levels, post-translational modifications, protein-protein interactions, and the cellular microenvironment. Molecular cell proteomics service provides a variety of technical means to reveal these complex regulatory networks and provide important information for understanding the nature of life activities.
Inês C. Santos. et al. Advances in Chemical Pollution, Environmental Management and Protection, 2017.
Figure 1. Application of Molecular Cell ProteomicsTechnology.
Services at MtoZ Biolabs
Leveraging advanced analytical platforms, MtoZ Biolabs has established molecular cell proteomics service platform, offering a wide range of professional services, including:
1. Cell Proteomics Analysis Services
Utilizing high-resolution mass spectrometers and automated cell sorting platforms, MtoZ Biolabs ensures precise and stable detection and analysis of cellular proteomes. The platform offers gentle sorting techniques, optical monitoring, minimal loss cell separation, and minimally invasive protein preprocessing methods.
2. Proteomics Analysis Services
(1) Provide protein identification services, including precise identification of key attributes such as molecular weight, isoelectric point, structure, and amino acid sequence.
(2) Provide quantitative proteomic analysis services, including isotope labeling and non labeled quantitative techniques, to provide quantitative information on proteins in different biological contexts.
(3) Provide protein sequencing services, including mass spectrometry based protein sequencing analysis and Edman degradation based protein N-terminal sequence analysis.
(4) Provide post-translational modification proteomics analysis services to analyze protein structures and their biological functions in living organisms.
3. 4D Proteomics Analysis Services
Offering 4D proteomics analysis powered by timsTOF Pro, supporting studies on trace sample proteomics, large cohort studies in medical research, and high-throughput modification proteomics.
4. Biologics Characterization and Macromolecular Mass Spectrometry Services
Providing mass spectrometry-based analysis for proteins, peptides, metabolites, and small molecules.
MtoZ Biolabs’ services encompass the entire workflow, from sample preparation to data analysis, delivering end-to-end proteomics solutions. Through these services, MtoZ Biolabs supports clients in achieving breakthroughs in fundamental research, molecular diagnostics, and other life science fields.
Figure 2. Flow Chart of Molecular Cell Proteomics Technology.
Service Advantages
1. Advanced Analytical Platform
MtoZ Biolabs has established advanced molecular cell proteomics service platform, ensuring reliable, fast, and high-precision analytical services.
2. Transparent Pricing
Our pricing is transparent, with no hidden or additional fees.
3. High-Quality Data
Our molecular cell proteomics service offers deep data coverage and strict quality control, providing clients with comprehensive data reports.
4. High Throughput
MtoZ Biolabs can handle large sample volumes efficiently, delivering results quickly without compromising quality.
5. Customizable Solutions
According to customer needs, provide personalized analysis program.
Applications
1. Biomarker and Drug Discovery
Molecular cell proteomics plays a pivotal role in identifying biomarkers and discovering drugs in healthcare. Chemical proteomics enables the screening of compound libraries, identifying all proteins interacting with these compounds, and evaluating potential drug side effects. For example, chemical proteomics has been applied to target heat shock protein 90 (HSP90) for clinical drug candidates.
2. Disease Diagnosis and Therapy
In medicine, molecular cell proteomics service facilitates understanding disease mechanisms and discovering new drug targets. Clinical proteomics provides insights into protein roles under various pathological conditions, advancing early diagnosis, prognosis, novel therapeutic target identification, and treatment response evaluation.
3. Agricultural and Plant Proteomics
Proteomics in agriculture supports crop quality improvement, disease resistance enhancement, and adaptability. By analyzing crop protein expression under varying environmental conditions, scientists can develop crop varieties better suited to specific environments.
4. Biomaterials Research
Molecular proteomics services explore the structure-function relationships of biomaterials such as silk fibroin, which hold great potential in biomedical and tissue engineering applications, including drug delivery and implantable device development.
5. Disease Research
Proteomics has been extensively applied to study conditions such as cancer and cardiovascular diseases, yielding significant progress.
Case Study
1. Cell Proteomics Plays a Key Role in the Study of Disease Mechanisms
Researchers isolated five types of liver cells (HC/KC/LSEC/CHC/HSC) and used the label-free quantification algorithm MaxLFQ for protein quantification. Statistical analysis with Perseus and R software identified 11,520 proteins, representing one of the largest organ proteome datasets to date. The study explored the correlation between transcriptomics and proteomics, revealing a degree of correlation but notable differences. This research provides valuable proteomic data for liver biology and disease studies.
Azimifar, S B. et al. Cell Metabolism, 2014.
Figure 3. Example of Label-Free Quantification: Mouse Liver.
MtoZ Biolabs demonstrates exceptional technical expertise in molecular cell proteomics service. With its advanced analytical platform, comprehensive service offerings, stringent data quality control, customizable research solutions, and outstanding team and technical support, MtoZ Biolabs delivers superior services and research outcomes to clients. Notably, the company excels in mass spectrometry analysis. By leveraging Thermo's Orbitrap series mass spectrometers combined with the Nano-LC system, MtoZ Biolabs ensures high precision and sensitivity in data acquisition. This integration allows for subcellular resolution insights into protein localization and abundance, providing a deeper understanding of protein functions within cells. Free project evaluation, welcome to learn more details!
How to order?