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    Methylation Protein Analysis Service

      Methylated proteins undergo modifications where methyl groups (-CH3) are added to specific amino acid residues, such as lysine and arginine. This process is catalyzed by methyltransferases, which transfer methyl groups from S-adenosylmethionine (SAM) to the amino acid residues. Methylation can result in mono-methylation (one methyl group), di-methylation (two methyl groups), or tri-methylation (three methyl groups).

       

      Methylation modifications are crucial for gene expression regulation, cell differentiation, signal transduction, and chromatin remodeling. Analyzing methylated proteins helps to: (1) Understanding mechanisms of gene expression regulation; (2) Exploring cell functions and signaling pathways; (3) Discovering disease biomarkers; (4) Developing novel therapeutic strategies.

       

      MtoZ Biolabs offers ubiquitinated protein analysis service, delivering high-quality data, offering deep insights into ubiquitination roles in biological processes to advancing research and clinical applications. Free project evaluation, welcome to learn more details! Our technical specialists are available to provide a free business assessment.

       

      Analysis Workflow

      1. Sample Collection and Processing

      Clients provide cell or tissue samples, and we perform protein extraction.

       

      2. Protein Digestion

      Employing efficient enzymatic digestion methods to ensure the production and consistency of peptides.

       

      3. Peptide Separation and Purification

      Utilizing high-resolution liquid chromatography for peptide separation.

       

      4. Mass Spectrometry Analysis

      Conducting high-sensitivity, high-resolution peptide detection and identification using advanced mass spectrometers.

       

      5. Data Analysis and Reporting

      Using professional data analysis software to identify methylation sites and provide detailed analysis reports.

       

      Applications

      1. Disease Research

      Identifying disease-related methylation markers to reveal disease mechanisms.

       

      2. Drug Development

      Screening potential drug targets and evaluating the impact of drugs on protein methylation.

       

      3. Biomarker Discovery

      Finding methylation markers related to specific biological processes or disease states.

       

      4. Gene Regulation Research

      Studying the role of methylation modifications in gene expression regulation.

       

      Service Advantages

      1. High Sensitivity and High Resolution

      Our service can accurately determine the mass-to-charge ratio (m/z) and the modification sites of peptides, enabling the detection of even low-abundance methylation modifications.

       

      2. Precise Localization of Modification Sites

      We can identify the exact location of methylation modifications (such as lysine or arginine residues), providing detailed structural information.

       

      3. Wide Applicability

      Our platform can analyze various types and complexities of biological samples, including cells, tissues, and body fluids, making it suitable for diverse biomedical research and clinical applications.

       

      Deliverables

      1. Experimental Procedures

      2. Relevant Mass Spectrometry Parameters

      3. Detailed Information on Methylation Protein Analysis

      4. Mass Spectrometry Images

      5. Raw Data

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