Metal Content Analysis Service

Metal content analysis is a technique for detecting and quantifying concentration of metal elements in samples, crucial for ensuring the efficacy and safety of bioproducts during their development and manufacturing. Common methods include atomic absorption spectroscopy (AAS), X-ray fluorescence (XRF), and inductively coupled plasma mass spectrometry (ICP-MS). AAS, a straightforward and cost-effective method, analyzes metal content by combusting the sample and measuring the absorbance of specific elements, though it generally measures only one element at a time and has higher detection limits. XRF, a non-destructive method causing minimal sample damage and suitable for the analysis of solid samples, determines elemental types and contents by exposing the sample to X-rays and analyzing the resulting fluorescence spectrum.

 



Figure 1. Display of Metal Content Analysis Results

 

ICP-MS determines the type and content of elements by creating a plasma and measuring the m/z of the plasma. It can analyze all metal elements in the periodic table and detect multiple elements simultaneously. It has a very low detection limit (below 1ppt), making it a significant tool in metal content analysis. MtoZ Biolabs has established a metal content analysis platform based on ICP-MS, which can qualitatively and quantitatively identify metal elements in various recombinant proteins/peptides/antibody drugs, protein vaccines, recombinant collagen, etc., and also provide other bioproduct characterization-related services. Welcome to contact to learn more about our service.

 

Deliverables

1. Experimental Procedures

2. Relevant Mass Spectrometry Parameters

3. Comprehensive Details on Metal Content Analysis

4. Mass Spectrometry Images

5. Raw Data

• • ICP-MS Based Metal Content Analysis Service

  ICP-MS (inductively coupled plasma mass spectrometry) is a high-sensitivity analytical technique used to measure the concentration of metal and non-metal elements in liquid samples. It induces coupled plasma in a high-frequency electromagnetic field, and the sample is ionized. A mass spectrometer is used to quantify the mass of the elemental ions to determine the concentration of each element in the sample. ICP-MS is characterized by high accuracy and precision, simple sample preparation and injection

• • ICP-MS Trace Element Detection Service

  Trace elements such as arsenic, chromium, cadmium, copper, iron, mercury, nickel, lead, and molybdenum, although present in very small contents in organisms, are essential for the growth, development, and physiological functions of organisms. Despite their low content, the insufficient or excessive intake of these elements can have adverse effects on organisms. Copper, iron, and molybdenum are essential for life activities, but can be toxic beyond certain concentrations.