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    L-Hydroxyproline Analysis Service

      L-Hydroxyproline is a crucial non-standard amino acid predominantly found in collagen. It plays a vital role in maintaining the structure and function of connective tissues, such as skin, bones, cartilage, and blood vessels. As a marker of collagen degradation, L-Hydroxyproline levels can indicate the status of collagen metabolism. Analyzing L-Hydroxyproline is essential for studying collagen metabolism, diagnosing connective tissue disorders, and assessing healing and repair processes.


      Variations in L-Hydroxyproline metabolism can be linked to numerous physiological and pathological conditions, including osteoporosis, arthritis, skin disorders, and liver fibrosis. Accurate measurement of L-Hydroxyproline levels provides valuable insights into the dynamics of collagen metabolism, serving as a scientific foundation for clinical diagnosis and treatment.



      Figure 1. Molecular Structure of L-Hydroxyproline


      MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of L-Hydroxyproline. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of L-Hydroxyproline in complex biological matrices.


      Analysis Workflow




      Service Advantages

      • Rapid Analysis Cycle and Cost-Effectiveness
      • Stable, Reliable, and Highly Sensitive Results
      • Comprehensive One-Stop Service for Extensive Testing Needs
      • User-Friendly Operation with Wide Application Scope
      • Supported by Extensive Bioanalytical Resources and Advanced Platforms


      Sample Submission Requirements

      Sample Types

      Serum, plasma, urine, tissue homogenates, and other biological samples.


      Sample Volume

      At least 200 μg of liquid sample or 200 mg of tissue sample.


      Sample Preservation

      Store and transport samples at -80°C to maintain L-Hydroxyproline stability.



      Clinical Diagnosis: Measure levels in patients with osteoporosis, arthritis, skin disorders, and liver fibrosis to assist in diagnosis and prognosis.


      Metabolic Research: Investigate the role and metabolic pathways of L-Hydroxyproline in collagen metabolism.


      Drug Development: Evaluate the impact of drugs on L-Hydroxyproline metabolism to aid in developing new therapeutic agents.


      Nutritional Research: Analyze the metabolic changes of L-Hydroxyproline under different dietary conditions, providing scientific evidence for nutritional regulation and dietary supplementation.



      1. Experimental Procedures

      2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

      3. Detailed Information on L-Hydroxyproline

      4. Raw Data

      5. Custom Analysis Report


      MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into L-Hydroxyproline's extensive physiological roles through top-tier analytical techniques and expert services.

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