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    L-4-Hydroxyproline Analysis Service

      L-4-Hydroxyproline is a crucial derivative of proline, predominantly found in collagen, essential for maintaining the structure and function of connective tissues. As a key component ensuring collagen stability and the formation of its triple helix structure, L-4-Hydroxyproline levels are important biomarkers for evaluating connective tissue metabolism and pathological conditions. Additionally, it plays vital roles in wound healing, tissue regeneration, and anti-aging processes. Accurate analysis of L-4-Hydroxyproline and its metabolites allows researchers and clinicians to understand its metabolic pathways and physiological roles, providing scientific evidence for diagnosing and treating connective tissue diseases, conducting nutritional assessments, and developing new drugs.



      Figure 1. Molecular Structure of L-4-Hydroxyproline


      MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of l-4-hydroxyproline and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of l-4-hydroxyproline in complex biological matrices.


      Analysis Workflow


      Experimental Instruments

      • Liquid Chromatography-Mass Spectrometry (LC-MS)
      • Gas Chromatography-Mass Spectrometry (GC-MS)
      • Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)


      Service Advantages



      Clinical Research: Monitor L-4-Hydroxyproline levels to study its role in connective tissue diseases (such as osteoporosis and fibrotic diseases) and other health conditions, aiding diagnosis and treatment.


      Nutritional Assessment: Analyze L-4-Hydroxyproline content in foods and supplements to evaluate nutritional value and guide dietary intake and supplementation strategies.


      Skin and Beauty Research: Assess the role of L-4-Hydroxyproline in skin health and anti-aging products, optimizing product formulations.


      Drug Development: Explore the potential applications of L-4-Hydroxyproline in new drug development, particularly for treating connective tissue diseases and wound healing.



      1. Experimental Procedures

      2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

      3. Detailed Information on L-4-Hydroxyproline

      4. Raw Data

      5. Custom Analysis Report


      MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into l-4-hydroxyproline's extensive physiological roles through top-tier analytical techniques and expert services.

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