Hydroxyeicosatetraenoic Acids (HETEs) Analysis Service

Arachidonic acid undergoes oxidation through several enzymatic pathways, including prostaglandin H2 synthase, 5-lipoxygenase, and cytochrome P450 enzymes-dependent epoxygenase reactions. These pathways utilize arachidonic acid as a substrate, leading to the production of various bioactive lipid mediators such as prostaglandins, thromboxanes, leukotrienes, and epoxyeicosatrienoic acids. In blood and vascular tissues, the primary metabolites of arachidonic acid are hydroxyeicosatetraenoic acids (HETEs). HETEs are linked to physiological processes such as cell aggregation, migration, and proliferation. HPLC followed by GC/selected ion monitoring is commonly employed for the sensitive and specific analysis of HETEs.

 

MtoZ Biolabs offers comprehensive analysis services for HETEs and their isomers, utilizing a system that ensures high stability, reproducibility, and sensitivity in separation, characterization, identification, and quantitative analysis, combined with LC-MS/MS techniques.

 

Services at MtoZ Biolabs

HETEs (5-, 8-, 9-, 11-, 12-, 15-, 20-HETE), HEPEs, and HDoHEs