HCP Identification and Relative Quantitative Analysis Service

    Host cell proteins (HCP) are proteins expressed by production cells and may remain in the final product during bioproduct manufacturing. HCP is a critical quality marker in the development and production of bioproducts, particularly recombinant protein drugs. Its presence can impact drug purity and stability and may trigger adverse immune responses. Thus, qualitative identification and relative quantification of HCP are essential in drug development and quality control. Qualitative identification of HCP verifies whether it presents in bioproducts and enables the precise identification of various HCPs within complex drug samples. Relative quantification of HCP assesses the relative abundance of HCP by comparing signal intensities in the samples, providing insights into the drug's quality and safety.


    MtoZ Biolabs has established a qualitative and quantitative analysis platform for HCP, utilizing Thermo's latest Orbitrap Fusion Lumos mass spectrometer and Nano-LC technology. This platform identifies all HCPs in bioproducts, providing  their information about names, pI, and MW, and employs PRM data collection for determining the relative contents of specific HCPs, facilitating the screening of high-risk HCPs and process optimization. The expert team at MtoZ Biolabs, with much experience in bioanalysis and drug development, offers personalized, efficient, and accurate analysis plans.  Leveraging advanced equipment and strict analysis process, we guarantee the highest service quality for each project. Free consultations are available for more details!



    1. Experimental Procedures

    2. Relevant Experiment Parameters

    3. Detailed Information on HCP Qualitative Identification and Relative Quantification Analysis

    4. Mass Spectrometry Images

    5. Raw Data

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