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    Febrifugine Analysis Service

      Febrifugine, an alkaloid derived from Dichroa febrifuga, widely known as Changshan, has been used for centuries in traditional Chinese medicine to reduce fever. Its structure is characterized by a quinazolinocarboline backbone, which disrupts malaria parasite development by inhibiting their ability to utilize nucleic acids and heme.

       

      In the liver, febrifugine undergoes metabolism predominantly through the cytochrome P450 (CYP) enzyme system, notably CYP3A4. This process yields several metabolites, notably demethylated Febrifugine, which maintains partial antimalarial efficacy though with diminished potency. Hydroxylation and glucuronidation further facilitate the drug’s excretion, critical for its elimination from the body. Understanding these pathways is vital for enhancing febrifugine's clinical use, maximizing therapeutic effects, and reducing adverse outcomes.

       

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      Figure 1. Molecular Structure of Febrifugine

       

      MtoZ Biolabs utilizes liquid chromatography-mass spectrometry (LC-MS) for metabolomic analysis of febrifugine. This technique combines the high separation efficiency of high-performance liquid chromatography (HPLC) with the high sensitivity of mass spectrometry (MS), allowing for the precise detection and quantification of trace components in complex samples. Our services extend beyond identification and quantification to include in-depth studies on the structure-activity relationships, metabolic pathways, and biological activity of alkaloids, providing comprehensive data support. 

       

      Analysis Workflow

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      Services at MtoZ Biolabs

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      Service Advantages

      • High Sensitivity and Accuracy: LC-MS technology can precisely identify and quantify trace components in complex samples.
      • Broad Applicability: Suitable for various biological samples, including plant tissues, blood, and urine.
      • Rapid Analysis: The process from sample handling to report generation is efficient, shortening the analysis cycle.
      • Customized Services: Personalized analysis solutions provided based on specific customer needs.

       

      Applications

      Drug Development: Detailed studies on febrifugine enable insights into its molecular interactions, supporting the development of novel antimalarial therapies.

       

      Pharmaceutical Quality Control: Rigorous analysis ensures that herbal formulations containing febrifugine adhere to safety standards, upholding product integrity.

       

      Pharmacokinetics: Investigations into febrifugine’s ADME profile are essential for optimizing dosage regimens, ensuring therapeutic efficacy while mitigating risks.

       

      At MtoZ Biolabs, we are dedicated to offering superior metabolomic analysis services for febrifugine, aimed at enhancing your understanding of its biological functions and assisting in the development and regulatory compliance of associated products. We are eager to support your research endeavors as a trusted scientific partner.

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