Exogenous Metabolite Analysis Service

    Exogenous metabolites refer to external chemical substances, which can be either toxic or harmless. These exogenous metabolites include not only drugs but also dietary supplements, food additives, and environmental pollutants. When exogenous metabolites significantly disrupt the metabolism and transport of endogenous compounds entering the body, they may harm human health. Exogenous metabolites can be metabolized directly by metabolic enzymes in the body. Studying how exogenous metabolites are metabolized in the human body helps us accelerate drug discovery and toxicological research. In drug discovery, understanding the metabolites of drugs aids in the study of the mechanism of action of the drugs. Moreover, metabolism can cause adverse side effects, hence understanding the metabolism of various chemicals is also very important in the field of toxicology. Metabolomics is a comprehensive analysis of small molecules and is an ideal tool for systematically analyzing endogenous metabolites. Metabolomics has many applications in xenobiotic research, such as the metabolism of acetaminophen (APAP), cyclophosphamide (CP), and ifosfamide (IF).

     

    MtoZ Biolabs relies on advanced analytical platforms and professional analysts and technicians to provide services for the analysis of exogenous metabolites, metabolite screening, and monitoring of exogenous metabolite/metabolite concentrations. We possess various high-throughput analytical technologies for exogenous metabolomics, such as ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS), gas chromatography mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR). For subsequent analysis, we offer multivariate data analysis, including but not limited to: principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal projections to latent structures discriminant analysis (OPLS-DA).

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