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    Citrulline Analysis Service

      Citrulline is a non-protein amino acid synthesized in the human body via the arginine pathway and plays a pivotal role in the urea cycle. As a significant metabolic intermediate, citrulline is involved in several physiological processes, including nitrogen excretion, immune system regulation, and vasodilation. Its role in enhancing exercise performance and recovery is well-documented, primarily through increased nitric oxide production, which improves blood flow and oxygen delivery.


      The unique functions of citrulline in health maintenance and exercise optimization make its precise metabolic analysis essential. Understanding its mechanisms of action within the body provides valuable data for clinical diagnostics, sports nutrition, and disease treatment.



      Figure 1. Molecular Structure of Citrulline


      MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of citrulline and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of citrulline in complex biological matrices.


      Analysis Workflow


      Services at MtoZ Biolabs

      Comprehensive Metabolite Analysis

      Identification and Quantification of Citrulline Derivatives

      Citrulline-Arginine Ratio Analysis


      Service Advantages



      Sample Submission Requirements


      For detailed sample submission instructions, please consult our technical team.



      Clinical Research: Monitoring citrulline levels to explore its role in liver, kidney, and cardiovascular diseases, aiding in diagnosis and treatment.


      Sports Nutrition: Assessing citrulline levels in athletes to optimize training regimens and recovery strategies, enhancing performance.


      Immune Regulation: Studying citrulline's involvement in immune responses and inflammation, offering insights for treating immune-related conditions.


      Drug Development: Investigating the potential of citrulline in new drug development, particularly for metabolic disorders and vascular diseases.



      1. Experimental Procedures

      2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

      3. Detailed Information on Metabolites

      4. Raw Data

      5. Custom Analysis Report

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