Cortexolone Analysis Service
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
Cortexolone (also known as 11-deoxycortisol, chemical formula C₂₁H₃₀O₄) is a steroid compound that serves as a precursor to glucocorticoids. Its structure, like other members of the steroid hormone family, consists of a steroid nucleus made up of four carbon rings (A, B, C, D rings). The main feature of cortexolone is the absence of a hydroxyl group (-OH) at the 11th carbon, hence the name 11-deoxycortisol. While cortexolone itself has relatively low biological activity, it is a critical precursor in the cortisol synthesis pathway. In certain experimental studies, cortexolone has been found to possess some anti-androgenic properties, particularly in dermatological applications. It can inhibit 5α-reductase activity, preventing the conversion of testosterone to dihydrotestosterone (DHT), thereby reducing the occurrence of DHT-induced skin conditions such as acne and hair loss. Cortexolone is metabolized by 11β-hydroxylase (CYP11B1) to produce cortisol, a process that occurs in the adrenal glands. Cortisol is a glucocorticoid with potent anti-inflammatory and immunomodulatory effects, playing a vital role in regulating numerous physiological processes in the body. The metabolism of cortexolone is essential for glucocorticoid production, especially under stress conditions when the demand for cortisol increases, with cortexolone serving as a precursor molecule for rapid conversion.
By analyzing biological samples (such as blood or urine) for cortexolone levels, one can gain insights into the dynamic changes in the glucocorticoid metabolic pathway, providing diagnostic information for adrenal disorders, stress responses, and endocrine imbalances. Additionally, the measurement of cortexolone and its metabolites can help in studying the balance of steroid hormone metabolism in the body and offer data to support the treatment of glucocorticoid-related diseases. Using highly sensitive analytical techniques such as mass spectrometry, cortexolone and its metabolites can be accurately quantified. This is crucial for a deeper understanding of steroid hormone metabolism in the human body, assessing the risks of related diseases, and exploring new therapeutic strategies.
Figure 1. The Structure of Cortexolone
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider, providing advanced metabolomics, proteomics and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. MtoZ Biolabs utilizes an LC-MS-based metabolomics research platform for the analysis of cortexolone. We ensure the accuracy of the quantification of cortexolone and its metabolites, as well as the comprehensiveness and precision of metabolite identification. If you are interested in our cortexolone analysis service, please feel free to contact us at any time, and we will be fully committed to providing you with high-quality analytical services and technical support.
Analysis Workflow
Service Advantages
1. Advance Analysis Platform: MtoZ Biolabs established an advanced cortexolone analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality: Extensive data coverage with rigorous quality control. Our advanced analysis platform consolidates all cortexolone analysis data, delivering clients a detailed and comprehensive data report.
4. Quick Turnaround: We offer a fast analysis process to ensure that clients receive high-quality data within a short time.
Applications
1. Finding novel disease biomarkers
2. Improving disease diagnosis
3. Accelerating the discovery of cutting-edge therapeutics
4. Revealing new insights into disease mechanisms
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues and other biological samples. It is required to select more than 3 materials of the same condition for each sample.
2. Sample Volume
3. Sample Preservation
Samples should be stored at -80°C to ensure stability.
Note: Please provide detailed information on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on Cortexolone
4. Raw Data
5. Custom Analysis Report
Our Cortexolone Analysis Service is designed to aid your research and product development by delivering precise and reliable results.
How to order?
