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    Berberine Analysis Service

      Berberine, an isoquinoline alkaloid extracted from plants such as Coptis chinensis, is recognized for its diverse therapeutic benefits. This potent natural compound is particularly effective in managing diseases like diabetes, cardiovascular disorders, and gastrointestinal issues. Berberine's efficacy is primarily attributed to its role in activating AMP-activated protein kinase (AMPK), which enhances cellular energy metabolism, thereby increasing insulin sensitivity and lowering levels of inflammation and cholesterol.

      Potential Health Benefits of Berberine

      • Treatment of Metabolic Diseases: Berberine has been shown to effectively manage blood glucose levels in individuals with Type 2 diabetes.
      • Cardiovascular Protection: It contributes to cardiovascular health by modulating lipid metabolism and reducing markers of inflammation.
      • Anti-inflammatory Effects: Studies indicate that berberine substantially reduces the production of pro-inflammatory cytokines, aiding in the reduction of chronic inflammation.
      • Antimicrobial Properties: Demonstrates effectiveness against a range of viral, bacterial, and fungal pathogens.



      Figure 1. Molecular Structure of Berberine


      MtoZ Biolabs utilizes liquid chromatography-mass spectrometry (LC-MS) for metabolomic analysis of berberine. This technique combines the high separation efficiency of high-performance liquid chromatography (HPLC) with the high sensitivity of mass spectrometry (MS), allowing for the precise detection and quantification of trace components in complex samples. Our services extend beyond identification and quantification to include in-depth studies on the structure-activity relationships, metabolic pathways, and biological activity of alkaloids, providing comprehensive data support.


      Analysis Workflow


      Services at MtoZ Biolabs


      Service Advantages

      • High Sensitivity and Accuracy: LC-MS technology can precisely identify and quantify trace components in complex samples.
      • Broad Applicability: Suitable for various biological samples, including plant tissues, blood, and urine.
      • Rapid Analysis: The process from sample handling to report generation is efficient, shortening the analysis cycle.
      • Customized Services: Personalized analysis solutions provided based on specific customer needs.


      Sample Submission Requirements

      • Tissue samples: ≥ 200 mg
      • Plasma samples: ≥ 200 μL
      • Blood samples: ≥ 200 μL
      • Pharmaceuticals: ≥ 0.2 g

      For detailed sample submission instructions, please consult our technical team.


      At MtoZ Biolabs, we are dedicated to offering superior metabolomic analysis services for berberine, aimed at enhancing your understanding of its biological functions and assisting in the development and regulatory compliance of associated products. We are eager to support your research endeavors as a trusted scientific partner.

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