Antibody Drug Ultraviolet Spectrum Analysis
Antibody drugs, as a breakthrough in biotechnology, are now widely used in the treatment of various diseases, including cancer, autoimmune diseases, and infectious diseases. These drugs are usually precisely designed protein molecules that can specifically bind to targets in the human body, such as specific molecules on pathogens or diseased cells, thereby guiding the attack of the immune system or directly blocking the pathological process. Due to the complexity and high specificity of antibody drugs, the requirements for analytical techniques in the development and quality control process are extremely strict. Ensuring the purity, concentration and conformational stability of the drug is crucial, which not only relates to the efficacy of the drug, but also affects its safety.
Ultraviolet spectroscopy technique is based on the absorption characteristics of antibody proteins to specific wavelengths of ultraviolet light, and can provide rapid and non-destructive detection of drug concentration and protein conformation. At a wavelength of 280 nanometers, aromatic amino acids in proteins (such as tryptophan, tyrosine, and phenylalanine) will absorb ultraviolet light, which is often used for quantitative analysis of the concentration of antibody drugs. Meanwhile, by comparing ultraviolet absorption spectra under different conditions, changes in the secondary and tertiary structure of proteins can be indirectly inferred, thereby monitoring the structural integrity of the drug. The high throughput and convenience of ultraviolet spectroscopy make it an ideal choice for early screening in drug development and quality control in the production process.
MtoZ Biolabs provides drug quality research services that comply with global pharmaceutical regulations, including one-stop antibody drug ultraviolet spectroscopy analysis services.
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