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    Aconitine Analysis Service

      Aconitine, a potent diterpene alkaloid, is chiefly derived from the traditional herb, Aconitum. Renowned for its profound analgesic properties, particularly in mitigating cancer-associated gastrointestinal pain, aconitine acts by inducing paralysis in peripheral nerves while also offering anti-inflammatory benefits. Despite its therapeutic potential, aconitine poses significant risks due to its high toxicity, affecting both the sensory and central nervous systems and directly impacting cardiac and vagal functions. Consequently, accurate and detailed analytical assessment of aconitine is critical.

       

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      Figure 1. Molecular Structure of Aconitine

       

      MtoZ Biolabs utilizes liquid chromatography-mass spectrometry (LC-MS) for metabolomic analysis of aconitine. This technique combines the high separation efficiency of high-performance liquid chromatography (HPLC) with the high sensitivity of mass spectrometry (MS), allowing for the precise detection and quantification of trace components in complex samples. Our services extend beyond identification and quantification to include in-depth studies on the structure-activity relationships, metabolic pathways, and biological activity of alkaloids, providing comprehensive data support.

       

      Analysis Workflow

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      Services at MtoZ Biolabs

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      Service Advantages

      • High Sensitivity and Accuracy: LC-MS technology can precisely identify and quantify trace components in complex samples.
      • Broad Applicability: Suitable for various biological samples, including plant tissues, blood, and urine.
      • Rapid Analysis: The process from sample handling to report generation is efficient, shortening the analysis cycle.
      • Customized Services: Personalized analysis solutions provided based on specific customer needs.

       

      Sample Submission Requirements

      • Fresh plant samples: > 1 g
      • Animal tissue samples: > 200 mg
      • Cell or bacterial samples: > 107, supernatant > 2 mL
      • Animal fluid samples: > 200 µL
      •  Lyophilized samples: > 0.5 g

      To ensure robustness and reliability of the analysis, submission of at least six biological replicates is recommended, with all samples maintained under controlled conditions to minimize variability and enhance the precision of the results.

       

      Applications

      Clinical Studies: Evaluating the effectiveness and side effects of aconitine in alleviating various types of pain.

       

      Regulatory Compliance: Ensuring the aconitine content in herbal medicinal preparations adheres to safety guidelines.

       

      Pharmacological Research: Investigating aconitine’s action mechanisms within biological systems, particularly its impact on the nervous system.

       

      At MtoZ Biolabs, we are dedicated to offering superior metabolomic analysis services for aconitine, aimed at enhancing your understanding of its biological functions and assisting in the development and regulatory compliance of associated products. We are eager to support your research endeavors as a trusted scientific partner.

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