5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid Analysis Service
- Accurately quantify 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid in biological samples
- Unravel the enzymatic pathways involved in its metabolism
- Understand the correlation between 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid levels and disease states
- Advanced Platform: Utilization of cutting-edge mass spectrometry platforms for high sensitivity and accuracy
- Expert Team: A team of experienced scientists dedicated to delivering reliable results
- Comprehensive Report: Detailed report with complete data analysis and interpretation
- Fast Turnaround: The process from sample handling to report generation is efficient, shortening the analysis cycle
- Biomarker discovery for various diseases
- Drug metabolism and pharmacokinetic studies
- Functional studies of lipid metabolism
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid, commonly known as leukotriene B4 (LTB4), is a potent inflammatory mediator derived from arachidonic acid. LTB4 is synthesized by leukotriene-A4 hydrolase from leukotriene A4 in response to inflammatory stimuli. As a critical component of the immune response, LTB4 facilitates the adhesion and activation of leukocytes on the endothelium, enabling them to migrate into inflamed tissues. In neutrophils, LTB4 functions as a potent chemoattractant, inducing the formation of reactive oxygen species (ROS) and promoting the release of lysosomal enzymes, thus enhancing the inflammatory process.
LTB4 is extensively studied due to its role in various inflammatory diseases, including asthma, atherosclerosis, and rheumatoid arthritis. Its ability to modulate immune cell behavior makes it a key target in the development of anti-inflammatory therapies. By understanding LTB4's activity, researchers can better elucidate the mechanisms underlying inflammation and disease progression.
Figure 1. The Structure of 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid
MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, providing advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption.
At MtoZ Biolabs, we offer comprehensive 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid analysis services using state-of-the-art mass spectrometry techniques. Our services can help you:
Analysis Workflow
Service Advantages
Applications
Our 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid analysis service can be applied to:
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice. Avoid repeated cycles of freezing and thawing
Note: Please provide details on sample collection and handling.
Deliverables
1. Comprehensive Experimental Details (Materials, Instruments, and Methods, etc.)
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid
4. Raw Data
5. Custom Analysis Report
Our 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid analysis service can provide valuable insights into the role of this metabolite in various biological processes and diseases. We look forward to assisting you with your research endeavors.
How to order?
