4-Hydroxyphenylpyruvic Acid Analysis Service

    4-Hydroxyphenylpyruvic Acid (4-HPPA) is an intermediate in the metabolism of amino acids phenylalanine and tyrosine. It is converted into homogentisate by the enzyme 4-hydroxyphenylpyruvate dioxygenase. Mutations in this enzyme lead to a condition called type III Tyrosinemia. 4-HPPA is also found in the human intestine and has been linked to the gut microbial metabolism. Understanding the metabolism of 4-HPPA can lead to the development of better disease treatments and dietary recommendations.

     

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    Figure 1. The Structure of 4-Hydroxyphenylpyruvic Acid

     

    Our team of experienced scientists at MtoZ Biolabs uses LC-MS/MS (liquid chromatography-mass spectrometry), providing accurate, reliable, and comprehensive analysis of 4-HPPA. Our advanced methodologies allow us to detect and quantify 4-HPPA, even in complex biological samples.

     

    Analysis Workflow

    1. Sample Preparation: We handle a variety of samples, including but not limited to, blood, urine, and tissue extracts.

    2. 4-HPPA Extraction: We use advanced techniques to isolate 4-HPPA from your samples.

    3. LC-MS/MS Analysis: Our state-of-the-art equipment allows for precise detection and quantification of 4-HPPA.

    4. Data Processing and Interpretation: Our team of bioinformaticians performs data analysis, including data normalization, multivariate statistical analysis, pathway analysis, etc.

    5. Report Generation: A comprehensive report with detailed analysis results and valuable insights is delivered to the clients.

     

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    Service Advantages

    • Highly Efficient Sample Recovery and Processing
    • Accurate and Reliable Detection and Quantification
    • Capability to Handle Various Sample Types
    • Customized Data Analysis Services
    • Rapid Service Response and Cost-Effectiveness

     

    Applications

    Our 4-HPPA analysis service can support various research fields, including:

    • Disease Mechanism Research
    • Drug Discovery
    • Nutrition Research

     

    Sample Submission Requirements

     

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    • Samples should be stored at -80℃ and shipped with dry ice.
    • We recommend providing at least 3 samples of similar conditions for each type of sample.
    • Other sample types, please contact us for more details.

     

    Deliverables

    1. Experimental Procedures

    2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

    3. Detailed Information on 4-Hydroxyphenylpyruvic Acid

    4. Raw Data

    5. Custom Analysis Report

     

    Contact us today to learn more about our 4-Hydroxyphenylpyruvic Acid Analysis Service.

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