Drug Target Analysis Service

• • HDX Based Protein Conformation Analysis Service

  Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is a mass spectrometry (MS) technique that studies protein spatial conformation. In this process, protein hydrogen atoms can exchange with deuterium atoms in heavy water. The hydrogen atoms of amide bonds on the protein surface or those involved in protein-ligand interactions exchange at a faster rate than those deeper within the protein or not involved in interactions.

• • Molecular Glue Screening Service | PROTAC Service

  Proteins play a pivotal role in the regulation, function, and structure of various human organs and tissues. The regulation of the synthesis and degradation of proteins is crucial for cell functionality. Protein turnover can exist in three states: equilibrium, pool expansion, and pool contraction. At equilibrium, the rate of protein synthesis matches that of degradation, leading to unchanged transcriptome and metabolome profiles.