Quantitative Proteomics
- Disease Mechanism Research
- Drug Development
- Clinical Research and Precision Medicine
- Biomarker Discovery
- Agricultural and Food Sciences
- Cell Signaling Pathway and Functional Studies
- Biopharmaceutical Development and Quality Control
Quantitative Proteomics is a critical branch of modern proteomics that aims to accurately measure the relative or absolute abundance of proteins in biological samples using a variety of analytical techniques. The core objective is to quantify protein expression levels and, by comparing changes in protein abundance under different experimental conditions, reveal the dynamic roles of proteins in biological processes. Through quantitative proteomics, researchers can compare protein expression profiles across various physiological and pathological states, uncovering condition-specific protein dynamics. This provides strong support for studies on disease mechanisms, drug development, and clinical biomarker discovery.
Bhargava M. et al. Clin Transl Med. 2014.
Figure 1. Principles of quantitative proteomics.
Services at MtoZ Biolabs
Relying on advanced mass spectrometry platforms, MtoZ Biolabs provides a series of Quantitative Proteomics services to help researchers accurately identify changes in protein expression levels under different experimental conditions, time points or treatment groups, and reveal their regulatory mechanisms in biological processes such as physiology, pathology, and drug response.
iTRAQ-based Quantitative Proteomics Analysis
An isotope-labeled quantitative proteomics method that allows simultaneous analysis of up to 10 samples. Ideal for large-scale, multi-condition differential protein expression studies.
SRM-MRM Quantitative Proteomics Services
Targeted protein quantification services based on triple quadrupole mass spectrometry technology utilize selected reaction monitoring (SRM) or multiple reaction monitoring (MRM) techniques to achieve high specificity and high sensitivity quantification of specific proteins in samples.
PRM Targeted Proteomics Analysis Service
A high-resolution mass spectrometry-based targeted quantification service using parallel reaction monitoring (PRM). Enables high-specificity and high-sensitivity quantification of specific proteins or peptides, suitable for validation studies and biomarker analysis.
DIA Quantitative Proteomics Analysis Service
High-throughput quantitative proteomics service based on data-independent acquisition (DIA). Offers comprehensive protein quantification in complex samples with high coverage, reproducibility, and accuracy.
Label-Free DIA Quantitative Proteomics
It combines the high throughput of label-free strategies with the broad coverage of DIA technology, making it ideal for large-scale proteomics studies.
DIA+PRM Target Proteomics Services
Targeted proteomics services that combine DIA and PRM technologies can not only achieve global protein screening, but also perform precise quantitative verification of candidate proteins with high specificity and sensitivity.
MSX-DIA Quantitative Proteomics Services
MSX-DIA is a variant of DIA that uses narrower acquisition windows and parallelized fragmentation to enhance quantification accuracy and proteome coverage. Especially useful for large-scale quantification of low-abundance proteins.
GPF-DIA Quantitative Proteomics Services
Utilizes a high-quality gas-phase fractionation (GPF) spectral library to boost peptide identification rates and quantification depth. Ideal for comprehensive proteomic analysis of highly complex samples.
Global Proteomic Quantification Service
Unbiased, high-resolution mass spectrometry-based proteomic quantification service. Delivers full-spectrum expression profiling of proteins across samples, supporting systems-level comparisons and mechanistic studies.
4D Label-free Quantitative Proteomics Analysis Service
Label-free quantification based on a four-dimensional high-resolution mass spectrometry platform. Provides enhanced quantification accuracy and deep proteome coverage, ideal for in-depth profiling of complex biological samples.
4D-PRM Target Proteomics Services
Combines four-dimensional mass spectrometry with PRM for high-precision targeted protein quantification. Incorporates ion mobility separation for highly specific, sensitive, and reproducible detection of target proteins within complex biological matrices.
Service Advantages
1. Advanced Analysis Platform: MtoZ Biolabs established an advanced Quantitative Proteomics platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrates all Quantitative Proteomics data, providing clients with a comprehensive data report.
4. Support for Multiple Quantification Methods: Offers a range of quantification techniques, including labeling methods such as iTRAQ and TMT, as well as label-free quantification strategies, to meet diverse research needs.
5. Compatibility with Various Sample Types: Whether working with tissues, cells, or body fluids, MtoZ Biolabs provides customized quantitative proteomics solutions tailored to different research fields and application requirements.
Applications
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)
4. Data Analysis, Preprocessing, and Estimation (project-dependent)
5. Bioinformatics Analysis
6. Raw Data Files
How to order?
