Resources
Proteomics Databases
Metabolomics Databases
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SRM proteomics (Selected Reaction Monitoring, SRM) is a highly sensitive mass spectrometry-based quantitative technique designed for the precise detection and quantification of target proteins in complex biological samples. By specifically monitoring selected peptide ions, SRM enables the high-specificity identification and quantification of proteins in complex biological matrices. The fundamental principle of SRM proteomics is the detection of precursor and fragment ions of specific peptides using a mass..
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Tear proteomics investigates the composition, function, and dynamic variations of proteins in tear fluid through comprehensive qualitative and quantitative analyses. As a physiological secretion, tear fluid not only lubricates and protects the ocular surface but also plays a crucial role in immune regulation, antimicrobial defense, and other physiological processes. With ongoing advancements in proteomics technologies, tear proteomics has become an increasingly valuable tool in ophthalmic research.......
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Biomarker validation is the process of confirming, through experimental and analytical methods, that a biomarker possesses diagnostic, prognostic, or therapeutic significance in a specific biological condition or disease. Biomarkers, which may include genes, proteins, or other biological molecules, often exhibit variations that correlate with particular diseases or physiological states. The purpose of validation is to ensure the reliability and clinical utility of biomarkers across various applications.....
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• Microbial Proteomics Analysis
Microbial proteomics analysis involves the comprehensive, high-throughput qualitative and quantitative analysis of proteins in microorganisms using advanced analytical techniques. This field has driven innovations in microbiology, environmental science, medicine, and bioengineering. As one of the most abundant groups of organisms on Earth, microorganisms play essential roles in diverse environments, including ecological systems, the human body, and various industrial applications. The study of microbial....
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• Multiple Reaction Monitoring Mass Spectrometry
Multiple Reaction Monitoring (MRM) is a mass spectrometry technique designed for the precise and sensitive detection and quantification of target compounds. Recognized for its high selectivity and sensitivity, MRM is particularly effective in identifying and quantifying specific analytes in complex biological matrices. This technique is widely utilized in proteomics, metabolomics, and pharmaceutical analysis. Multiple reaction monitoring operates based on tandem mass spectrometry (MS/MS), selectively ......
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• Protein-Protein Interactions by Co-Immunoprecipitation
Protein-protein interactions by co-immunoprecipitation is used to study the physical association between a protein and its interacting partners in cells or tissues. This method relies on the use of a specific antibody to capture a target protein, allowing for the co-precipitation of its interacting partners. Protein-protein interactions are fundamental to numerous cellular processes, including signal transduction, metabolic regulation, and gene expression. Co-IP not only facilitates the characterization....
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Unbiased proteomics is a field of modern life sciences that aims to comprehensively and systematically analyze all proteins present in a sample, both in terms of type and quantity. Unlike traditional targeted proteomics, which focuses on a predefined set of proteins, unbiased proteomics utilizes high-throughput mass spectrometry to detect all proteins in a sample without prior selection. This approach provides a comprehensive overview of the protein landscape, facilitates the discovery of novel biomarkers..
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TMT 18plex is a high-throughput protein quantification technique based on tandem mass tag (TMT) technology, enabling the simultaneous relative quantification of up to 18 samples within a single experiment. TMT technology employs a chemical labeling strategy in which isotope-coded tags are covalently attached to the N-terminus or lysine residues of peptides, facilitating the distinction and quantification of proteins from different samples during mass spectrometry analysis. The introduction of TMT 18plex....
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• Protein Co-Immunoprecipitation
Protein co-immunoprecipitation (Co-immunoprecipitation, Co-IP) is a classical biochemical technique used to study protein-protein interactions. This method is based on the principle of antigen-antibody specific binding, using specific antibodies to enrich the target protein while simultaneously capturing its interacting proteins, thereby identifying the composition of protein complexes. Protein co-immunoprecipitation enables the study of direct or indirect interactions between proteins under near-physio....
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SP3 (Single-Pot Solid-Phase Enhanced Sample Preparation) proteomics is an efficient, streamlined, and highly automated protein sample preparation technique that has gained widespread adoption in mass spectrometry-based proteomics. Conventional proteomic workflows typically require multiple complex steps, including protein extraction, denaturation, reduction, alkylation, enzymatic digestion, and peptide purification. These processes are not only labor-intensive and time-consuming but also prone to protein...
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