Resources
Proteomics Databases
Metabolomics Databases
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• How to Detect Histone Propionylation Modifications?
Post-translational modifications (PTMs) of histones represent a crucial level of epigenetic regulation. Among them, propionylation, an emerging type of acylation, has received widespread attention in recent years. Propionylation modulates chromatin structure and transcriptional activity by altering the charge and spatial conformation of lysine residues and plays a key role in processes such as metabolic regulation, tumorigenesis, and inflammatory responses. With advances in high-resolution mass spectr......
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• What Does Histone Khib Mean in Epigenetic Regulation?
In the past decade, the development of high-resolution mass spectrometry has significantly advanced research on protein post-translational modifications (PTMs). Beyond classical modifications such as acetylation and methylation, a new class of lysine acylations has attracted increasing attention. Among these, lysine β-hydroxyisobutyrylation (Khib) has emerged as a prominent focus in epigenetic research. What Is Histone Khib Modification? Khib is a novel acylation occurring on lysine residues and was ......
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• Antibody Sequencing Service: How to Evaluate a Provider for Sequence Recovery Projects
Learn how to evaluate an antibody sequencing service for unknown-sequence recovery projects, including sample suitability, de novo sequencing workflow credibility, sequence annotation quality, validation planning, and usable deliverables for recombinant recovery.
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• De Novo Antibody Sequencing: Sample Requirements, Feasibility, and Expected Outputs
Technical guide for de novo antibody sequencing sample readiness, feasibility review, expected deliverables, and validation planning.
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Learn a practical workflow for de novo sequencing using mass spectrometry data, from precursor review and MS/MS spectrum annotation to candidate sequence ranking, ambiguity handling, and orthogonal validation for unknown peptide identification.
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• De Novo Sequencing Method vs Database Search: Which Strategy Fits Novel or PTM-Rich Peptides?
Compare de novo sequencing method, database search, and hybrid LC-MS/MS workflows for novel peptides or PTM-rich samples.
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Technical guide for de novo protein sequencing mass spectrometry in unknown protein characterization, undocumented peptides, sequence variants, and impurity-related peptide projects.
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Learn when mass spec de novo sequencing is justified after LC-MS/MS database search failure and follow a stepwise workflow for unknown peptide identification, spectrum triage, PTM-aware interpretation, and validation planning.
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• How to Evaluate a De Novo Peptide Sequencing Service for Unknown Peptide Identification Projects
Technical guide for evaluating a de novo peptide sequencing service for unknown peptide identification projects.
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• Exosome Proteomics: Key Techniques and Applications
Exosomes are membrane-bound vesicles actively secreted by various cell types, with diameters ranging from 30 to 150 nm. They are enriched in proteins, nucleic acids (including miRNAs and lncRNAs), and lipids, and can be internalized by recipient cells to regulate a wide range of biological processes. Among the diverse molecular components of exosomes, proteins are not only highly abundant but also closely associated with their biological functions. Systematic identification of functional exosomal prot......
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