Resources

Proteomics Databases



Metabolomics Databases

• • Tandem Affinity Purification | TAP-MS | Technique to Study Protein-Protein Interactions

  A technical guide to TAP-MS covering tandem affinity purification principles, workflow steps, advantages, limitations, and applications in protein-protein interaction studies.

• • Affinity Purification Mass Spectrometry (AP-MS)

  A technical guide to affinity purification mass spectrometry AP-MS, covering workflow steps, controls, comparison with Co-IP MS, and applications in protein interaction discovery.

• • Protein Identification, Quantification, PTM Mapping, or Intact Mass: Which Mass Spectrometry Service Do You Need?

  A comparison guide to choosing among protein identification, quantification, PTM mapping, and intact mass mass spectrometry services based on project question, sample type, and deliverable needs.

• • When Protein Mass Spectrometry Results Are Inconclusive: Common Causes and How to Improve Analytical Confidence

  A problem-solving guide to inconclusive protein mass spectrometry results, covering common causes from sample prep to reporting and practical steps to improve analytical confidence.

• • MS-Based Polyclonal Antibody Sequencing vs. BCR-Seq: Which Strategy Fits Your Antibody Discovery Project?

  Compare MS-based polyclonal antibody sequencing and BCR-seq for antibody discovery, covering sample input, repertoire depth, protein-level confirmation, and strategy selection by project goal.

• • Proteomics Service for Protein Identification, Quantification, and PTM Profiling

  A practical guide to proteomics services covering protein identification, quantification, and PTM profiling, with selection criteria and next steps for project planning.

• • Why Polyclonal Antibody Sequencing Is Challenging: Mixture Complexity, Low-Abundance Clones, and CDR Coverage Gaps

  Learn why polyclonal antibody sequencing is challenging due to mixture complexity, low-abundance clone loss, and CDR coverage gaps, and how enrichment and layered MS improve resolution.

• • Protein Mass Spectrometry Facility

  A practical guide to protein mass spectrometry facilities covering capability areas, selection criteria, facility types, and next steps for protein and biologics sample projects.

• • Planning a Native MS Project: What to Confirm Before Submitting Protein Complex or Biologics Samples

  A practical planning guide to what to confirm before submitting protein complex or biologics samples for native MS, covering question framing, buffer, purity, partners, and shipping.

• • Polyclonal Antibody Sequencing: How Complex Antibody Mixtures Can Be Resolved by MS-Based and Sequence-Guided Analysis

  Learn how complex polyclonal antibody mixtures are resolved by MS-based de novo analysis and sequence-guided contig assembly, including deconvolution workflow, mass constraints, and reporting outputs.