Resources

Proteomics Databases



Metabolomics Databases

• • PhIP-Seq Study Design for Disease and Control Cohorts

  A practical guide to PhIP-Seq study design for disease and control cohorts, covering inclusion criteria, control matching, sample size, matrix and library choice, batch planning, and analysis alignment.

• • How Many Control Samples Are Needed for PhIP-Seq?

  A practical guide to PhIP-Seq control sample planning, covering control types, minimum numbers by study design, case-control balance, and matrix-matched control requirements.

• • Why PhIP-Seq Candidates Require Orthogonal Validation

  A technical guide explaining why PhIP-Seq candidates require orthogonal validation, covering false-confidence sources, validation pathways, and phased confirmation before autoantigen claims.

• • How to Interpret Enriched Peptides in Autoantibody Studies

  A practical guide to interpreting enriched peptides in autoantibody studies, covering normalization, control contrast, protein mapping, PTM context, and confidence tier assignment.

• • How PhIP-Seq Supports Candidate Autoantigen Discovery

  A technical guide explaining how PhIP-Seq supports candidate autoantigen discovery through library screening, enrichment analysis, protein mapping, and structured validation handoff.

• • PhIP-Seq for Autoantibody Profiling

  A technical overview of PhIP-Seq for autoantibody profiling covering workflow steps, library design, data outputs, applications, and validation planning.

• • Serum vs Plasma vs CSF for Autoantibody Profiling

  A comparison guide to serum, plasma, and CSF for autoantibody profiling covering matrix differences, study goal selection, handling requirements, and workflow implications.

• • How to Prioritize Candidate Autoantigens after PhIP-Seq

  A practical guide to prioritizing candidate autoantigens after PhIP-Seq using filtering, ranking criteria, tiered validation, and orthogonal confirmation workflows.

• • Can PhIP-Seq Detect Conformational or Modified Autoantigens?

  A technical guide explaining whether PhIP-Seq can detect conformational or modified autoantigens, covering library design limits, PTM variant screening, and validation paths for autoimmune serology.

• • Planning a Polyclonal Antibody Sequencing Project: Sample Requirements, Reference Data, and Validation Strategy

  Plan a polyclonal antibody sequencing project by addressing sample purity, reference data integration, and validation tiers before MS analysis begins.