Resources

Proteomics Databases



Metabolomics Databases

• • LC-MS/MS-Based Identification of Histone Malonylation Sites

  Histone malonylation, as a novel post-translational modification (PTM) of histones, has attracted extensive attention in epigenetic research in recent years. Unlike acetylation and methylation, malonylation regulates chromatin structure and gene expression, playing critical roles in cell proliferation, differentiation, and metabolic regulation. However, its low abundance and diverse modification forms present significant challenges for study. Owing to its high sensitivity and throughput, liquid chroma......

• • How to Identify Histone Malonylation Sites?

  In the current era of rapid advances in epigenetics and proteomics, histone post-translational modifications (PTMs) have emerged as critical indicators for understanding gene expression regulation. Among these modifications, histone malonylation has garnered significant attention due to its close association with cellular metabolic states, representing an emerging area in the intersection of metabolism and epigenetics. Nevertheless, compared to classical modifications such as acetylation and methylati......

• • PhIP-Seq Sample Requirements and Submission Guidelines

  Introduction For many antibody profiling projects, the largest cost risk is not sequencing itself—it is sample uncertainty before the experiment begins. A serum or plasma set may look ready for analysis, yet unclear cohort grouping, low sample volume, repeated freeze-thaw cycles, or missing clinical metadata can create delays. In discovery studies, these issues may also weaken interpretation because PhIP-Seq results depend on both sample quality and study design. Sample requirements matter because th......

• • How Antibody Repertoire Sequencing Supports Discovery Programs—and Where It Differs From Defined Antibody Sequencing

  Technical guide for How Antibody Repertoire Sequencing Supports Discovery Programs—and Where It Differs From Defined Antibody Sequencing.

• • How to Design a Workflow for Histone Khib Site Identification?

  In life science research, post-translational modifications (PTMs) of histones remain a central focus in epigenetics. In recent years, lysine 2-hydroxyisobutyrylation (Khib), a novel PTM of histones, has attracted considerable attention. Khib not only influences chromatin structure and gene expression, but is also closely associated with energy metabolism, cell proliferation, and tumorigenesis. Therefore, precise identification of histone Khib sites is essential for a comprehensive understanding of the......

• • How to Analyze Histone Propionylation by LC-MS/MS?

  With the rapid advancement of epigenetic research, histone post-translational modifications (PTMs) have emerged as key approaches for elucidating gene regulatory mechanisms. Among these, histone propionylation (Histone Propionylation, Kpr), an emerging lysine acylation modification, has attracted increasing attention due to its close association with cellular metabolic states. However, its low abundance, site complexity, and high similarity to other acylation modifications present significant challeng......

• • RACE Antibody Sequencing for Clone Recovery: When to Choose It Before Outsourcing

  Technical guide for RACE Antibody Sequencing for Clone Recovery: When to Choose It Before Outsourcing.

• • Antibody Next-Generation Sequencing vs Mass Spectrometry Antibody Sequencing: Which Fits Your Sample Source?

  Technical guide for Antibody Next-Generation Sequencing vs Mass Spectrometry Antibody Sequencing: Which Fits Your Sample Source?.

• • Mass Spectrometry Antibody Sequencing for Protein-Only Samples: How to Plan the Right Recovery Strategy

  Technical guide for Mass Spectrometry Antibody Sequencing for Protein-Only Samples: How to Plan the Right Recovery Strategy.

• • Antibody Amino Acid Sequencing: What You Can Recover From a Purified Antibody Sample

  Technical guide for Antibody Amino Acid Sequencing: What You Can Recover From a Purified Antibody Sample.