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    Procyanidin B3 Analysis Service

      Polyphenols are the largest group of secondary metabolites in plants, and their structural determination has been a focal point in research. Among polyphenols, procyanidin, also known as condensed tannins, are derived from proanthocyanidins. Procyanidin and proanthocyanidins are ubiquitously present in the plant kingdom and are commonly found in varying concentrations in everyday foods such as fruits, vegetables, legumes, grains, and nuts, as well as in cosmetics and pharmaceuticals containing plant materials. As natural antioxidants, procyanidins are used to stabilize food color, prevent rancidity caused by the oxidation of unsaturated fats, and for the chemoprevention of various degenerative tumors. Besides their antioxidant properties, procyanidin have reported anticancer, anti-infection, anti-inflammatory, cardioprotective, antibacterial, antimutagenic, wound healing, antidiabetic, and antiallergic activities.

       

      Procyanidin B3 consists of two catechin units linked by B-type bonds (C4-C8). This compound is typically found in barley, apples, and grapes. It exhibits antioxidative, antibacterial, and antiviral properties. Procyanidin B3 is primarily utilized in food additives and nutritional supplements, particularly for the prevention of cardiovascular diseases.

       

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      Figure 1. The Structure of Procyanidin B3
       

      Services at MtoZ Biolabs

      1. Detectable Procyanidins at MtoZ Biolabs

       

      1808768378396594176-花青素可以检测的物质.PNG 

       

      2. Procyanidins Analysis Techniques

      • High-Performance Liquid Chromatography (HPLC): For separating and quantifying different types of proanthocyanidins.
      • Mass Spectrometry (MS): Combined with HPLC to provide molecular weight and structural information of proanthocyanidins.
      • Nuclear Magnetic Resonance (NMR): For detailed molecular structure analysis of proanthocyanidins.
      • Spectroscopy (e.g., UV-Vis and FTIR): For preliminary identification and quantitative analysis.

       

      3. Procyanidin B3 Targeted Metabolomics Analysis

       

      1808768588728356864-代谢组学分析流程.PNG

      Figure 2. The Workflow of Targeted Metabolomics for Procyanidin B3
       
       

      Applications

      1. Relieving Parkinson’s Disease

       

       1808768829678538752-应用1.PNG

       

      Chen, J. et al. Molecules. 2022.

       

      Proanthocyanidins, oligomeric compounds composed of catechin and epicatechin monomers, are widely present in food and hold significant medicinal value. Utilizing the LC-MS technology platform, MtoZ Biolabs provides qualitative and quantitative analysis of procyanidin B3 with exceptional sensitivity, reproducibility, and accuracy, expanding the research on its biological activities and medicinal value.

       

      Deliverables

      1. Experimental Procedures

      2. Relevant Mass Spectrometry Parameters

      3. Detailed Information on Procyanidin B3 Analysis

      4. Mass Spectrometry Images

      5. Raw Data

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